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Remote ischemic preconditioning is one way to influence the success of therapy in cardiovascular patients. By means of remote ischemic preconditioning the incidence of atrial fibrillation after cardiac surgery was reduced by 54%. The investigators aim to investigate the effect of ischemic preconditioning in an easy-to-perform protocol with regard to the recurrence of atrial fibrillation after electrical cardioversion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Remote Ischemic Preconditioning | Active Comparator | Remote ischemic preconditioining |
|
| Control | Sham Comparator | Sham preconditioning |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote ischemic preconditioning | Procedure | Remote ischemic preconditioning through inflation of a blood pressure cuff to pressure values > 200mmHg for 5 minutes followed by 5 minutes of reperfusion (3 times each) before electrocardioversion Electrical cardioversion for atrial fibrillation (100, 150, 200 Joule) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of subjects with recurrence of atrial fibrillation 30 days after electrical cardioversion | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with short-term cardioversion success | Sinus rhythm lasting > 30 seconds after electrocardioversion | 30 seconds |
| Minimum energy required for successful electrocardioversion (in Joule) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Josefs-Hospital Wiesbaden | Wiesbaden | Hesse | 65189 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40433224 | Derived | Keim C, Wiedenmann L, Schubert T, Rothe M, Dobre BC, Kaess BM, Ehrlich JR, Boehmer AA. Remote Ischemic Preconditioning for Electrical Cardioversion of Atrial Fibrillation-the Prospective Randomized PRECON-AF Study. CJC Open. 2025 Mar 10;7(5):571-578. doi: 10.1016/j.cjco.2025.03.004. eCollection 2025 May. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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|
| Sham preconditioning | Procedure | Inflation of a blood pressure cuff to pressure values ~ 10mmHg for 5 minutes followed by 5 minutes of reperfusion (3 times each) before electrocardioversion |
|
| 30 days |
| Cumulative energy applied for successfull electrocardioversion (in Joule) | 30 days |
| Cumulative number of shocks delivered for successfull electrocardioversion | 30 days |
| Number of patients experiencing death from any cause, stroke /transient ischemic attack, relevant post-ECV arrhythmia and procedure-associated complications | Safety endpoint | 30 days |
| D013568 |
| Pathological Conditions, Signs and Symptoms |