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Endpoints were investigated in parallel in NCT00877305
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| Name | Class |
|---|---|
| Goethe University | OTHER |
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The purpose of this study is to evaluate the effects of Remote Ischemic Preconditioning on cardiac function in patients undergoing cardiac surgery compared to control intervention.
In detail, we will focus on new onset of atrial fibrillation, ventricular arrhythmias, myocardial injury, and cardiac function. Furthermore, we aim to investigate underlying pathways of RIPC in modifying the perioperative stress response.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RIPC | Active Comparator |
| |
| CONTROL | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote Ischemic Preconditioning | Procedure | RIPC will be induced during anesthesia by four 5-min cycles of upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 15 mm Hg greater than the systolic arterial pressure measured via the arterial line. |
| Measure | Description | Time Frame |
|---|---|---|
| New onset of atrial fibrillation | Within 30 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Ventricular arrhythmias, myocardial injury, cardiac function. Underlying pathways of Remote Ischemic Preconditioning in modifying the perioperative stress response. | Within 24 hours after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Frankfurt am Main | Germany | ||||
| University Hospital Schleswig-Holstein |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| Control/sham procedure | Procedure | Sham placement of the blood pressure cuff around the upper limb without inflation. |
|
| Kiel |
| 24105 |
| Germany |
| D013568 |
| Pathological Conditions, Signs and Symptoms |