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slow recruitment
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Recent studies indicate that remote ischemic conditioning can protect the heart and other organs during cardiac surgery. The investigators aim to investigate whether such a stimulus can reduce the incidence of atrial fibrillation or other complications following coronary artery bypass surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preconditioning | Experimental | The remote ischemic stimulus will be applied after induction of anaesthesia, but before cardiopulmonary bypass. |
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| Postconditioning | Experimental | The remote ischemic stimulus during cardiopulmonary bypass. |
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| Pre and postconditioning | Experimental | The remote ischemic stimulus will be applied twice, after induction of anaesthesia and during cardiopulmonary bypass. |
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| Control | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remote ischemic conditioning | Procedure | Patients will have a automated inflator cuff placed on the upper arm during surgery. The cuff will be used to induce fore arm ischemia by inflation to 200 mmHg for 3 x 5 minutes, interspersed with 5 minutes of no-inflation and thus reperfusion. |
| Measure | Description | Time Frame |
|---|---|---|
| Post-operative atrial fibrillation | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Major cardiovascular and cerebrovascular events | Major adverse events, i.e. death, acute coronary syndrome, stroke. | 3 months, 6 months, 1 year |
| Length of stay | Duration of hospitalization and stay on the ICU |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stef de Hert, Md, PhD | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Academic Medical Center, University of Amsterdam | Amsterdam | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21605453 | Derived | Brevoord D, Hollmann MW, De Hert SG, van Dongen EH, Heijnen BG, de Bruin A, Tolenaar N, Schlack WS, Weber NC, Dijkgraaf MG, de Groot JR, de Mol BA, Driessen AH, Momeni M, Wouters P, Bouchez S, Hofland J, Luthen C, Meijer-Treschan TA, Pannen BH, Preckel B. Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial). BMC Anesthesiol. 2011 May 23;11:11. doi: 10.1186/1471-2253-11-11. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| C005703 | salicylhydroxamic acid |
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|
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| Sham | Procedure | Patients will have a automated inflator cuff placed on the upper arm during surgery which will not be inflated. |
|
| 1 week on avarage |
| D013568 |
| Pathological Conditions, Signs and Symptoms |