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The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on acute postprandial glucose regulation of plant based lipids. Due to the tight connection between cardiometabolic health and cognitive functions, a secondary issue is to investigate effects of test foods on cognitive test variables and mood parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| WWB Reference | Other | White wheat bread (WWB) without lipid supplements. The effects of this high glycaemic product on postprandial glucose and insulin responses are well studied. |
|
| WWB 5g active lipids | Experimental | WWB supplemented with 5 g active lipids, and 10 g control lipids |
|
| WWB 10g active lipids | Experimental | WWB supplemented with 10g active lipids, and 5 g control lipids |
|
| WWB 15g active lipids | Experimental | WWB supplemented with 15g active lipids, and 0 g control lipids |
|
| WWB 15 g control lipids | Active Comparator | WWB supplemented with 15g control lipids |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lipids | Dietary Supplement | Investigations of dose-response effects of 3 different doses of an bioactive plant based lipid consumed at breakfast, after overnight fasting. Total amounts of lipids in each test portion are 15g, and the lower doses are supplemented with a control lipid to sum upp to 15 g total lipids. A control product with15g control lipids and without active lipids is also included. The lipids are supplemented to a white wheat bread, corresponding to 50 g available starch. A White wheat bread portion without lipid supplementation is included as a well studied reference product. |
| Measure | Description | Time Frame |
|---|---|---|
| glucose tolerance | Postprandial blood glucose responses | 3 hours. Fasting (time =0), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin responses | Postprandial insulin responses | 3 hours. Fasting (time =0 minutes), 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes |
| Mood variables | Registration of subjective mood ratings (valence and activity) on 0-100 mm Visual Analogue Scales (VAS) at fasting and thereafter every hour until 180 min. Extremes of the sensations of the variables is at the two ends of the scales, i.e. 0 mm relates to the extrem of low senations sensations and 100 mm correspond to the highest sensation of the variables. |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive test variable | Pilot study. Computerised test measuring aspects of selective attention, working memory and psychomotor reaction time | 60 minutes after start of breakfast, after 120 minutes, and after 180 minutes |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Anne Nilsson | Lund | Välj... | 22100 | Sweden | ||
| The Human Trial Facility, Food Technology engineering and Nutrition, Lund University |
There is a plan to make Individual Participant Data (IPD) and related data dictionaries available. The data will be published in a scientific journal as supplementary material simultaneously as the study results. The test persons names are coded and no individual participant can be identified.
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D008055 | Lipids |
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|
| 60 minutes after start of test product, after 120 minutes and after 180 minutes |
| Appetite sensations | Subjective sensations of hunger, satiety, and desire to eat are registered on 0-100 mm VAS scales. Extremes of the sensations of the variables is at the two ends of the scales, i.e. 0 mm relates to the extrem of low senations sensations and 100 mm correspond to the highest sensation of the variables. | 3 hours. Fasting (time =0), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes |
| Lund |
| Välj... |
| 22100 |
| Sweden |
| D004700 | Endocrine System Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |