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| Name | Class |
|---|---|
| Chongqing University Jiangjin Hospital | UNKNOWN |
| Chongqing Medical University | OTHER |
| The People's Hospital of DAZU ，Chongqing | UNKNOWN |
| Xiangya Hospital of Central South University |
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To compare the anti-nausea and vomiting effect between glycopyrronium and ondansetron for patients receiving elective surgery under general anesthesia. Based on this study the investigators intend to explore the feasibility of using glycopyrronium to prevent postoperative nausea and vomiting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glycopyrronium | Experimental | Glycopyrronium (0.2mg) was intravenously given at the ending of the surgery. |
|
| Ondansetron | Active Comparator | Ondansetron (4mg) was intravenously given at the ending of the surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glycopyrronium | Drug | Glycopyrronium (0.2mg) was intravenously given at the ending of the surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| incidence of postoperative nausea and vomiting | postoperative nausea and vomiting is recorded according to follow-up visits after surgery | from the ending of surgery to 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| intensity of postoperative nausea | intensity of postoperative nausea is assessed using Numeric Rating Scale (0-10, 0 represents no uncomfortable felling, 10 represents tolerableness) | from the ending of surgery to 24 hours after surgery |
| incidence of postoperative vomiting |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain intensity | Pain intensity is assessed by numerical rating scale (0-10, 0 represents painless; 10 represents intolerable pain) | from the ending of surgery to 24 hours after surgery |
| Postoperative analgesic requirements |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guangyou Duan, MD | Contact | (+86)18323376014 | duangy@hospital.cqmu.edu.cn | |
| Dagang Wang, MD | Contact | +86 023 63693014 | kuanrenlunli@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| He Huang, MD | The Second Affiliated Hospital, Chongqing Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Second Affiliated Hospital, Chongqing Medical University | Recruiting | Chongqing | Chongqing Municipality | 400010 | China |
The individual participant data for this study is available from the sponsor on reasonable request through email.
Within five years
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| ID | Term |
|---|---|
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009325 | Nausea |
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| ID | Term |
|---|---|
| D006024 | Glycopyrrolate |
| D017294 | Ondansetron |
| ID | Term |
|---|---|
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009861 | Onium Compounds |
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| OTHER |
| West China Hospital | OTHER |
| The People's Hospital of Tongliang District， Chongqing city | UNKNOWN |
| Chongqing Medical Center for Women and Children | OTHER |
| Dianjiang People's Hospital of Chongqing | UNKNOWN |
| The Ninth People's Hospital of Chongqing | UNKNOWN |
| The People's Hospital of Yubei District of Chongqing city | UNKNOWN |
| Chongqing Yongchuan District People's Hospital | UNKNOWN |
| The First People's Hospital Of Chongqing Liang Jiang New Area | UNKNOWN |
| ChongGang General Hospital | UNKNOWN |
| The People's Hospital of Nanchuan | UNKNOWN |
| People's Hospital of Pengshui County | UNKNOWN |
| Yunyang people's Hospital | UNKNOWN |
| Chongqing Liangping District People's Hospital | UNKNOWN |
| Jiulongpo People's Hospital of chongqing | UNKNOWN |
| The People's Hospital of Qijiang District，Chongqing | UNKNOWN |
| University-Town Hospital of Chongqing Medical University | OTHER |
| Chongqing Public Health Medical Center | OTHER |
| CHONGQING BANAN HOSPITAL OF TCM | UNKNOWN |
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| Ondansetron | Drug | Glycopyrronium (4mg) was intravenously given at the ending of the surgery. |
|
postoperative vomiting is recorded according to follow-up visits after surgery |
| from the ending of surgery to 24 hours after surgery |
| incidence of intervention requirement for nausea and vomiting | this event is recorded according to follow-up visits after surgery | from the ending of surgery to 24 hours after surgery |
Analgesic requirements is assessed by recording the volume of patient controlled analgesia pump
| from the ending of surgery to 24 hours after surgery |
| degree of satisfaction | degree of satisfaction is assessed by patient using numerical rating scale (0-10, 0 represents unsatisfactory; 10 represents complete satisfaction) | from the ending of surgery to 24 hours after surgery |
| adverse reaction related to glycopyrronium and ondansetron | adverse reaction is recorded according to follow-up visits after surgery | from the ending of surgery to 24 hours after surgery |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D014839 | Vomiting |
| D011759 |
| Pyrrolidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D002227 | Carbazoles |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006575 | Heterocyclic Compounds, 3-Ring |