Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting

Effects of Ondansetron Dose and Timing on Rates of Post-operative Nausea and Vomiting

The aim is to evaluate the effectiveness of three different regimens of prophylactic ondansetron on the incidence and severity of post-operative nausea and vomiting.

Patients will be randomize to one of three arms: 4mg ondansetron pre-emergence, 8 mg ondansetron pre-emergence, or 4mg ondansetron pre-incision followed by 4mg ondansetron pre-emergence. Primary outcome will be incidence of PONV in the PACU prior to discharge.

Inclusion Criteria:

• ASA I, II, III presenting for ambulatory surgery to be performed under general anesthesia

Exclusion Criteria:

• Patients with allergies or contraindications to study medications