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| Name | Class |
|---|---|
| Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University ( Foshan Maternity & Child Healthcare Hospital) | UNKNOWN |
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Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.
Use cohort research to analyze and compare eyes of healthy children and children with systemic diseases. Understand and analyze the incidence, characteristics and influencing factors of children's ocular surface diseases. Establish a multi-center children's eye data sharing platform to provide basic data support for the diagnosis and treatment of children's ocular surface diseases.
All participants will be recruited from Zhongshan Ophthalmic Center, Sun Yat-sen University and Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University. Only children with written informed consent from their parents can participate in this study.
Participants will be excluded for (1) age>18; (2) previous use of orthokeratology lenses or low-concentration atropine; (3) allergy to compound tropicamide eye drop; (4) any history of ocular surgery.
All participants will undergo optometry and biometric measurements by a trained team. The axial length (AL), central corneal thickness (CCT), anterior corneal radii of curvature, anterior chamber depth (ACD), lens thickness (LT), the curvature power of the central flat meridian (K1) and the central steep meridian (K2), the ocular surface and fundus will be measured. All measurements will be taken in room light condition (1000 lux).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| children with systemic diseases | Systemic diseases such as Nephritic syndrome, and other systemic diseases that can affect the eyes. | ||
| healthy children | The exclusion criteria for the subjects were eye diseases or other systemic diseases that can affect the quality or volume of tears or the secretion of tears. These included
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| Measure | Description | Time Frame |
|---|---|---|
| change of the non-invasive tear break-up time | change of the non-invasive tear break-up time in seconds | baseline, 24th months |
| change of the lipid layer of tear film | change of the lipid layer of tear film in nanometers | baseline, 24th months |
| Measure | Description | Time Frame |
|---|---|---|
| vision | spherical equivalent in diopters | baseline, 6th months, 12th months, 18th months, 24th months |
| intraocular pressure | the intraocular pressure in mm Hg |
| Measure | Description | Time Frame |
|---|---|---|
| ocular surface disease index | It's a scale for the diagnostic score of dry eye. The total score ranges from 0 to 100, with higher scores indicating more severe symptoms. | baseline, 6th months, 12th months, 18th months, 24th months |
Inclusion Criteria:
Exclusion Criteria:
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Choose suitable patients from the ophthalmology hospital outpatient clinic or the ophthalmology and pediatric outpatient clinics of the Maternal and Child Health Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yingting Zhu | Contact | 13580585671 | ytzhu16@163.com | |
| Rui Xie | Contact | 17673125119 | sherie97@163.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36114405 | Derived | Wang Z, Xie R, Luo R, Yao J, Jin L, Zhou Z, Chen K, Zhuo X, Zhu Y, Zhuo Y. Comparisons of Using Cycloplegic Biometry Versus Non-cycloplegic Biometry in the Calculation of the Cycloplegic Refractive Lens Powers. Ophthalmol Ther. 2022 Dec;11(6):2101-2115. doi: 10.1007/s40123-022-00569-w. Epub 2022 Sep 16. |
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| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| baseline, 6th months, 12th months, 18th months, 24th months |
| Eye axis length | Eye axis length in millimeters | baseline, 6th months, 12th months, 18th months, 24th months |
| Anterior chamber depth | Anterior chamber depth in millimeters | baseline, 6th months, 12th months, 18th months, 24th months |
| central corneal thickness | central corneal thickness in millimeters | baseline, 6th months, 12th months, 18th months, 24th months |
| Lens thickness | Anterior chamber depth in millimeters | baseline, 6th months, 12th months, 18th months, 24th months |
| Retina thickness | retina thickness in millimeters | baseline, 6th months, 12th months, 18th months, 24th months |
| choroid thickness | choroid thickness in millimeters | baseline, 6th months, 12th months, 18th months, 24th months |
| Corneal curvature | Corneal curvature in diopters | baseline, 6th months, 12th months, 18th months, 24th months |
| non-invasive tear break-up time | non-invasive tear break-up time in seconds | 6th months, 12th months, 18th months |
| the lipid layer of the tear film | the lipid layer of the tear film in nanometers | 6th months, 12th months, 18th months |