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Through a systematic observational study, the intrinsic connections and patterns between the occurrence and development of common blinding retinal diseases such as diabetic retinopathy, pathological myopia, and age-related macular degeneration and the changes in fine parameters of the anterior structure of the eye are deeply explored. To achieve this goal, investigators will adopt cutting-edge multimodal imaging technology to simultaneously collect precise data from ocular surface and fundus of participants. By integrating and analyzing these multi-dimensional information from different parts of the same eye, investigators will build a high-quality and standardized ocular surface-fundus associated image database. This database not only aims to reveal potential ocular surface biomarkers that can be used for early warning or auxiliary diagnosis, but also lays a solid data foundation for the future development of artificial intelligence-assisted diagnostic tools and the establishment of a brand-new ocular surface-fundus integrated diagnosis and treatment assessment model.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inflammatory-Related Ocular Disease Group | |||
| Non-Inflammatory-Related Ocular Disease Group |
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| Measure | Description | Time Frame |
|---|---|---|
| Tear Break-Up Time | The time from the last complete blink to the appearance of the first dry spot on the cornea. | Baseline and within 30 days post-procedure |
| Dry Eye Questionnaire-5 | The DEQ-5 comprises five items assessing the frequency of dryness, discomfort, and watery eyes, as well as the late-day intensity of dryness and discomfort. Patients rate each item on a 0-4 or 0-5 scale, and the total score is summed. Higher scores indicate greater dry eye symptom severity. | Baseline and within 30 days post-procedure |
| Meibomian Gland Dropout | Meibomian gland dropout will be measured using infrared meibography. | Baseline and within 30 days post-procedure |
| Blink Rate | Blink rate will be measured using a video recording system under natural blinking conditions. The number of complete blinks and incomplete blinks per minute will be counted separately. | Baseline and within 30 days post-procedure |
| Lipid Layer Thickness | Lipid layer thickness refers to the thickness of the lipid layer of the tear film, which is the outermost layer of the precorneal tear film. | Baseline and within 30 days post-procedure |
| Tear Meniscus Height | Tear meniscus height refers to the vertical height of the tear volume accumulated along the lower eyelid margin. | Baseline and within 30 days post-procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Central Subfield Thickness | Central subfield thickness refers to the thickness of the retina at the fovea. | Baseline and within 30 days post-procedure |
| Subfoveal Choroidal Thickness | Subfoveal choroidal thickness refers to the thickness of the choroid directly beneath the fovea. |
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Inclusion Criteria:
Exclusion Criteria:
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The study population includes patients with both inflammatory and non-inflammatory ocular diseases.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tongren Hospital | Recruiting | Beijing | China |
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| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D015862 | Choroid Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D014603 | Uveal Diseases |
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| Baseline and within 30 days post-procedure |
| Subretinal Fluid | Subretinal fluid refers to fluid accumulation in the potential space between the neurosensory retina and the retinal pigment epithelium. | Baseline and within 30 days post-procedure |
| Intraretinal Fluid | Intraretinal fluid refers to fluid accumulation within the retinal layers, typically appearing as cystoid spaces. | Baseline and within 30 days post-procedure |
| Pigment Epithelial Detachment Height | Pigment epithelial detachment height refers to the maximal vertical height of separation of the retinal pigment epithelium from the underlying Bruch's membrane. | Baseline and within 30 days post-procedure |