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| Name | Class |
|---|---|
| Medical University of Vienna | OTHER |
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Substrate metabolism during exercise can be influenced by various nutritional regimes. The effectiveness of the different nutritional regimes, which differ in their carbohydrate content, will be investigated not only by functional tests but also the measurement of the mechanistic processes in the muscle will be explored.
Magnetic resonance (MR), better known as magnetic resonance imaging (MRI), has been widely used in clinical practice as a non-invasive imaging technique. Importantly, in addition to producing anatomical images, an MR scanner also offers the possibility to measure the concentrations of a number of metabolic products. This is done through a technique known as magnetic resonance spectroscopy (MRS).
This research project asks the following questions:
In active recreational athletes, the objectives are: (1) to investigate the effects of different diets with variable carbohydrate content and glycaemic index on substrate metabolism, (2) to determine the effects of the different diets on energy stores using multinuclear dynamic magnetic resonance spectroscopy, and (3) to measure the effects of the different diets on endurance performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low GI | Experimental | The subjects eat 55-60 E-% carbohydrates with ≥ 65 % from low glycaemic index carbohydrates per day, the other E-% are fats and proteins. |
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| High GI | Active Comparator | The subjects eat 55-60 E-% carbohydrates with ≥ 65 % from high glycaemic index carbohydrates per day, the other E-% are fats and proteins. |
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| Low Carb High Fat | Experimental | The subjects eat ≥ 65 E-% fats and a maximum of 50 g carbohydrates per day. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training intervention | Other | The training intervention will be a 10 week training plan for endurance runners. The plan consists of five sessions per week (three basic endurance sessions and two interval sessions) |
| Measure | Description | Time Frame |
|---|---|---|
| changes in peak oxygen consumption (measured in ml/min/kg) | VO2peak will be assessed during a graded exercise test on the treadmill. | Baseline - 10 weeks |
| changes in 5 km time trial (measured in mm:ss) | 5 km time trial performance will be assessed during an all out 5 km run on a 400 m running track. The time for completing the 5 km will be assessed. | Baseline - 10 weeks |
| changes in muscle glycogen content (measured in mmol/l muscle) | Changes in muscle glycogen will be assessed in a thigh muscle using a MR scan. | Baseline - 10 weeks |
| changes in power at lactate turning point 1 (LTP1) and individual anaerobic threshold (IAS) (measured in km/h) | Changes in power at LTP1 and IAS will be assessed during a graded exercise test on a treadmill. | Baseline - 10 weeks |
| changes in AUC in lactate in the graded exercise test | Changes in AUS in lactate will be assessed during a graded exercise test on a treadmill. | Baseline - 10 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| changes in fat free mass (measured in kg) | Changes in fat free mass will be assessed using a bioelectrical impedance analysis. | Baseline - 5 weeks - 10 weeks |
| changes in fat mass (measured in kg) |
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Inclusion Criteria:
Exclusion Criteria:
MRI-specific exclusion criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Vienna | Vienna | 1070 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38600291 | Derived | Moitzi AM, Krssak M, Klepochova R, Triska C, Csapo R, Konig D. Effects of a 10-Week Exercise and Nutritional Intervention with Variable Dietary Carbohydrates and Glycaemic Indices on Substrate Metabolism, Glycogen Storage, and Endurance Performance in Men: A Randomized Controlled Trial. Sports Med Open. 2024 Apr 10;10(1):36. doi: 10.1186/s40798-024-00705-9. |
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| High Glycaemic Index | Other | The subjects eat 55-60 E-% carbohydrates with ≥ 65 % from high glycaemic index carbohydrates per day, the other E-% are fats and proteins. |
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| LCHF | Other | The subjects eat ≥ 65 E-% fats and a maximum of 50 g carbohydrates per day. |
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| Low Glycaemic Index | Other | The subjects eat 55-60 E-% carbohydrates with ≥ 65 % from low glycaemic index carbohydrates per day, the other E-% are fats and proteins. |
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Changes in fat mass will be assessed using a bioelectrical impedance analysis.
| Baseline - 5 weeks - 10 weeks |
| changes in skeletal muscle mass (measured in kg) | Changes in skeletal muscle mass will be assessed using a bioelectrical impedance analysis. | Baseline - 5 weeks - 10 weeks |
| changes in body water (measured in l) | Changes in total and extracellular body water will be assessed using a bioelectrical impedance analysis. | Baseline - 5 weeks - 10 weeks |
| changes in body weight (measured in kg) | Changes in body weight will be assessed using a bioelectrical impedance analysis. | Baseline - 5 weeks - 10 weeks |
| changes in body mass index | Changes in body mass index will be assessed using a bioelectrical impedance analysis. The weight and the height will be used to calculate changes in BMI in kg/m^2. | Baseline - 5 weeks - 10 weeks |
| completion time of a half marathon performance (measured in hh:mm:ss) | The half marathon performance will be assessed during an official marathon race. The time of completion of the half marathon will be assessed. | after 10 weeks |
| changes in cholesterin and cholesterin subunits (measured in mg/dl) | Changes in cholesterin and cholesterin subunits (LDL and HDL cholesterin) will be assessed with a routine blood count. | Baseline - 10 weeks |
| changes in rated perceived exhaustion (RPE) in 5 km time trial | The changes in RPE will be assessed during the 5 km time trial on a running track. The RPE scale ranges from 6 to 20, where 20 means "really, really exhausting". | Baseline - 10 weeks |