The Newborn Infant Parasympathetic Evaluation (NIPE) was developed as a method of analysis of the heart rate variability. The monitor gives a value between 0 (low value of the parasympathetic component) and 100 (high value of the parasympathetic component).

So far, the measure of the heart failure variability by using the NIPE in infant born very premature ventilated and sedated in neonatal reanimation has not been realised and validated as an evaluation method of the pain and discomfort related to neonatal care.

Inclusion Criteria:

• Infant born very premature before 34 weeks of amenorrhoea + 0 day
• Age ≤ 7 days
• Admitted in neonatal reanimation
• Sedated, intubated, ventilated

Exclusion Criteria:

• High frequency oscillation ventilation
• Heart rate non sinusal
• Inotropes and atropine
• Opposition from the guardian of parental authority
• Difficulty of comprehension or communication making the parental information impossible

Infant born very premature and aged less than 8 days ventilated and sedated in neonatal reanimation