Newborn Infant Parasympathetic Evaluation (NIPE) Index After Standardized Tetanic Stimulations Under General Anesthesia

Newborn Infant Parasympathetic Evaluation (NIPE) Index After Three Standardized Tetanic Stimulations (10, 30 and 60 Miliamps) Performed in a Randomized Sequence Under General Anesthesia in a Pediatric Population

NIPE monitor is the recently developed pediatric version of the ANI monitor, which is used in adults to monitor analgesia during general anesthesia. In adults, under general anesthesia, ANI decreases after a nociceptive stimulation. The amplitude of this decrease is related to the intensity of the stim. This study aims to investigate if NIPE index decreases in the same manner after stimulations in anesthetized children.

Inclusion Criteria:

• Elective surgery under general anesthesia requiring tracheal intubation and muscle relaxation
• Written informed consent obtained from parents (and from child if appropriate)

Exclusion Criteria:

• Thoracic or cardiac surgery
• Cardiac arrhythmia, Pace maker
• Analgesic medication less than 24 hours before surgery
• Chronic anticholinergic medication
• Contraindication to muscle relaxants or general anesthetics