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This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients suffering from visual field defects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cf-tACS (V1-Alpha_V5-Gamma) | Active Comparator |
| |
| Cf-tACS (V1-Gamma_V5-Alpha) | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cross-frequency dual-site tACS | Other | Dual site transcranial alternating current stimulation over the primary visual cortex (V1) and the mediotemporal cortex (MT/V5) using two different stimulation frequencies (Alpha and Gamma) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in visual field functions | Comparison of the systematic measurement of the visual field using Humphrey perimetry | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in motion discrimination and integration performances | Comparison of the motion coherence threshold extracted from a two forced-choice direction discrimination task | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) |
| Changes in inter-areal cross-frequency interaction |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Campus Biotech, EPFL | Geneva | 1201 | Switzerland |
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| ID | Term |
|---|---|
| D014786 | Vision Disorders |
| D020521 | Stroke |
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D005128 | Eye Diseases |
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Double (Participant & Investigator)
Comparison of the inter-areal Alpha-Gamma coupling using electroencephalography recordings |
| Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) |
| Changes in visual tracts integrity | Comparison of the diffusion weigted imaging-based tractography of the main visual tracts | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) |
| Changes in functional connectivity within the broad visual network | Functional MRI based connectivity analyses using DCM or graph theory will perfomed | Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention) |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |