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tACS has the potential to directly induce cortical alterations in the intrinsic neural oscillation at specific frequencies, and the brain could mirror the induced frequencies of the external source of oscillations from the stimulation. Hence, tACS with matching stimulation frequency could be an effective means of enhancing brain oscillatory activity to potentially induce synaptic plasticity for restoration of damaged brain functions. However from the existing studies of applying tACS over the M1 in healthy and diseased brains, there is a wide range of applied stimulation frequencies and varied neuromodulation effects on motor behavior or cortical excitability at different frequencies. In this proposal, subject-specific stimulation frequency and latency will be identified.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| subject-specific tACS | Experimental | Constant current (1mA) will be applied for 20min at subject-specific stimulation frequency and latency |
|
| standard tACS | Experimental | Constant current (1mA) will be applied for 20min at 20Hz with a fixed 25ms latency |
|
| Sham tACS | Sham Comparator | The stimulator will be shut down after 30s of stimulation. The patients will feel the initial itching sensation at the beginning in order to evaluate the placebo effect |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tACS | Device | A pair of 25 cm2 rubber electrodes enclosed in saline-soaked sponges and affixed to the head with rubber bands. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Magnetic resonance imaging | Structural and functional MRI | 3-month after the 10th session training |
| Measure | Description | Time Frame |
|---|---|---|
| Action Research Arm Test (ARAT) | The ARAT has total 19 items, divided into 4 categories (grasp, grip, pinch, and gross arm movement). It ranges from 3 to 0 (best to worse). | 3-month after the 10th session training |
| Fugl-Meyer Assessment (Upper Extremity) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Raymond Tong, PhD | Contact | +852 3943 8454 | kytong@cuhk.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Raymond Tong, PhD | Department of Biomedical Engineering, The Chinese University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Biomedical Engineering, The Chinese University of Hong Kong | Recruiting | Shatin | Hong Kong |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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The maximum score is 66, divided into 33 items in the form of a 3-point scale (0-2), 0 is cannot perform and 2 performs fully. |
| 3-month after the 10th session training |
| Wolf Motor Function Test (WMFT) | The WMFT measures upper limb ability through timed and functional tasks. It has 17 items, ranging from 0 to 5 (worse to best). | 3-month after the 10th session training |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |