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The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for motor recovery in stroke survivors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tACS Sham, tACS 10Hz, tACS 20Hz | Experimental | tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns. |
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| HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham | Experimental | tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns. |
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| HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham | Experimental | tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tACS Sham | Device | Sham tACS will applied to the brain through the scalp for 20 minutes. |
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| Measure | Description | Time Frame |
|---|---|---|
| Block and Box Test (BBT) of Motor functional test | The Box and Block Test (BBT) measures unilateral gross manual dexterity. It is a quick and simple test used with a wide range of populations, including clients with stroke. | Change of BBT performance 5 minutes before and 5 minutes after the tACS intervention will be measured. |
| EEG alpha band and Beta band | Electroencephalography (EEG) is valuable to infer and evaluate the neural interaction. Components of the alpha and beta frequency bands like the sensorimotor rhythm originated from the primary motor cortex and related brain areas reflect human movement. The power of 8-13 Hz alpha and 14-30 Hz beta frequency bands will be used for the classification. | Change of EEG alpha band and Beta band 5 minutes before and 5 minutes after the tACS intervention will be measured. |
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Inclusion/exclusion criteria for stroke subjects
Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sheng Li, MD, Ph.D | Contact | (713) 797-7125 | sheng.li@uth.tmc.edu | |
| Shengai Li, MS | Contact | 713-797-7561 | shengai.li@uth.tmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Sheng Li, MD, Ph.D | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center | Recruiting | Houston | Texas | 77030 | United States |
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| tACS 10Hz | Device | 10Hz tACS will applied to the brain through the scalp for 20 minutes. |
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| tACS 20Hz | Device | 20Hz tACS will applied to the brain through the scalp for 20 minutes. |
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