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The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for neuropathic pain management in people after spinal cord injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| "tACS Sham, tACS 10Hz, tACS 20Hz" experimental order | Experimental |
|
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| "HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham" experimental order | Experimental |
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| "HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham" experimental order | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tACS Sham | Device | Sham tACS will applied to the brain through the scalp for 20 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain scale (visual analogue scale, VAS) measurement | The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between "no pain" and "worst pain." | Change of VAS 5 minutes before and after the tACS intervention will be measured. |
| Heart rate variability (HRV) measurement | Heart rate variability (HRV) is the fluctuation in the time intervals between adjacent heartbeats (1). HRV indexes neurocardiac function and is generated by heart-brain interactions and dynamic non-linear autonomic nervous system (ANS) processes. HRV will be used as a surrogate assessment for autonomic nerve system | Change of HRV 10-15 minutes before and after the tACS intervention will be measured. |
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Inclusion/exclusion criteria for SCI subjects
Inclusion criteria: A patient who
NOTE: we plan to begin the study with the spinal cord injury (SCI) subject population as a cohort first, then expand to other subject populations
Exclusion criteria: Patients will be excluded if they
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sheng Li, MD, Ph.D | Contact | (713) 797-7125 | sheng.li@uth.tmc.edu | |
| Shengai Li, MS | Contact | 713-797-7561 | shengai.li@uth.tmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Sheng Li, MD, Ph.D | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center | Recruiting | Houston | Texas | 77030 | United States |
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| ID | Term |
|---|---|
| D009437 | Neuralgia |
| ID | Term |
|---|---|
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D010146 | Pain |
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|
| tACS 10Hz | Device | 10Hz tACS will applied to the brain through the scalp for 20 minutes. |
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| tACS 20Hz | Device | 20Hz tACS will applied to the brain through the scalp for 20 minutes. |
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| D009461 |
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |