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Idiopathic hypersomnia (IH) is characterized by non-restoring night-time sleep, excessive daytime sleepiness, sleep inertia, impaired cognitive functioning and autonomic symptoms. IH seems to be long lasting, once established, but little is known about long-time consequences, and research on the relationship between idiopathic hypersomnia and all-cause mortality is however sparse. IH is thus a poorly characterized disorder of hypersomnolence, and the present study aims to answer the following research questions:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Idiopathic hypersomnia | Observation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polysomnography | Other | Reviewing collected data |
|
| Measure | Description | Time Frame |
|---|---|---|
| Polysomnography | Spectral analyses | Baseline |
| Multiple sleep latency test | Sleep latency and REM latency | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Morbidity | Diagnoses | 1 week |
| Sick leave | Percent | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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Eligible subjects are 185 individuals with idiopathic hypersomnia (IH) assessed and diagnosed using polysomnography and multiple sleep latency test at the Sleep unit, Uppsala university hospital between 2010-01-01 and 2019-12-31. Inclusion criteria is IH, according to the ICSD-3.
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| Name | Affiliation | Role |
|---|---|---|
| Rolf Karlsten, PhD | Uppsala University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University | Uppsala | 75185 | Sweden |
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| ID | Term |
|---|---|
| D020177 | Idiopathic Hypersomnia |
| ID | Term |
|---|---|
| D006970 | Disorders of Excessive Somnolence |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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| Pharmacotherapy |
Type and dosage |
| 1 week |
| Epworth Sleepiness Scale | Score on a scale with a total score of 0 to 24. Higher values means more severe problems. | Baseline |
| Sleep Problem Acceptance Questionnaire | Score on a scale. An 8-item self-report questionnaire, total scores range from 0 to 48 points. Higher values equals higher level of acceptance and a positive outcome. | 1 week |
| Insomnia Severity Index | Score on a scale. Seven items with a total score ranging from 0 to 28 points. Higher values means more severe insomnia, a negative outcome. | Baseline |
| Montgomery Åsberg Depression Rating Scale | Score on a scale. Higher score indicates more severe depression, a negative outcome. The overall score ranges from 0 to 60. | Baseline |
| Diurnal Type Questionnaire | Score on a scale. The overall score ranges 0 to 21, and higher scores equals more of a delayed sleep phase. | Baseline |
| Munich Parasomnia Screening | Score on a scale. 21 items with an overall score ranging from 0 to 84. Higher scores indicates a negative outcome. | Baseline |
| The Ullanlinna Narcolepsy Scale | Score on a scale. 11 item with a total score ranging 0-44. Higher total score equals a negative outcome. | Baseline |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |