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Idiopathic hypersomnia (IH) is a rare and poorly studied disease characterized by excessive daytime sleepiness different from that of narcolepsy (sleep drunkness non-recuperative naps and nocturnal blackout). Local sleep is a recent concept, proposing a local regulation of the sleep-wake state, characterized by slow waves (SW) restricted to certain regions of a globally awake brain. The investigators are going to investigate whether local sleep could explain the sleepiness of these patients better than the global occurrence of sleep which are not very frequent during daytime tests in IH.
The investigators propose to look for local sleep through the detection of local slow waves in the EEG of resting wakefulness and during an attentional task in people with IH compared to people with NT1 (sleepy, but with a different type of sleepiness from IH, more abrupt and including REM sleep) and non sleepy people.
Local sleep is a recent concept, suggesting a local regulation of the sleep-wake state, characterized for example in wakefulness by slow waves restricted to certain regions of a globally awake brain, correlating with modifications of mental experience and behavior. Although the phenomenon of local sleep has been demonstrated following acute sleep deprivation, its importance in explaining attentional fluctuations during a normal day is only beginning to be investigated. Moreover, inter-individual variations remain unexplored. The investigators propose to study in EEG (64 electrodes) the occurrence of local sleep in different states of sleepiness, in particular in idiopathic hypersomnia (IH) in comparison to that of narcolepsy type 1 (NT1) and to non-drowsy individuals, both in the resting state and during a sustained attention test (SART). This study will provide a better understanding of intra- (over the course of a day) and inter-individual fluctuations in the local sleep phenomenon potentially involved in this disease and its impact on cognition.
Anticipated number of participants:
60 including:
Practical procedure:
Single visit: presence from 9:30 am to 3:30 pm
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Idiopathic Hypersomnia | Experimental |
| |
| Narcolepsy type 1 | Active Comparator |
| |
| Healthy subject | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EEG (64 electrodes) | Other | EEG recording while awake, at rest then during an attentional cognitive test |
|
| Measure | Description | Time Frame |
|---|---|---|
| local sleep topography | Density and topography of local sleep through the detection of local slow waves (SW) during resting wakefulness and during a daytime attentional test in IH, narcolepsy and healthy subjects | At enrollment visit |
| Measure | Description | Time Frame |
|---|---|---|
| Daytime dynamics of local sleep | Density and topography of local sleep through the detection of local slow waves at two times of the day. | At enrollment visit |
| behavioral implications of local sleep |
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Inclusion Criteria:
Inclusion Criteria :
Healthy subjects and people with IH and NT1:
->18 years old, of both sexes, without legal protection.
Specific to people with IH:
-Diagnosis of IH according to the ICSD-3, already made in the sleep pathology department of the Pitié after a specialized medical interview and a standardized 48h assessment (Night 1+TILE+Night 2+two naps): Sleep time > 660 min or TILE latency <8 min, <2 SOREMPs.
Specific to people with NT1:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Isabelle Arnulf, MD, PhD | Contact | 01 42 16 77 04 | isabelle.arnulf@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Isabelle Arnulf, MD, PhD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pitié Salpêtrière | Paris | France |
|
The data will be confidential until their publication in a peer reviewed journal. Sharing will be feasible after, in case of reasonable request to the PI.
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| ID | Term |
|---|---|
| D020177 | Idiopathic Hypersomnia |
| ID | Term |
|---|---|
| D006970 | Disorders of Excessive Somnolence |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
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| Cognitive task (SART) | Other | Sustained attention go-no-go task (press a button each time a number is presented on a screen (1/second) except when the 3 appears) Assessment of mental status approximately every 45 seconds (task focus, mind wandering, mental blank, and sleepiness status) |
|
| Pupillometry and eye tracking | Other | Study of pupil size and gaze path during the cognitive test (correlated with alertness) |
|
| Thoracoabdominal belts | Other | Abdominal and thoracic belts (used in all nocturnal polysomnographic recordings) for respiratory movement studies (correlated with sleepiness) |
|
Correlation of slow wave characteristics to mental experience and performance (reaction time, omission, impulsivity) during the sustained attention task.
| At enrollment visit |
| correlation between local sleep and behavioral marker of alertness | Correlation of pupillometric and eye tracking measurements, respiratory and heart rate parameters (assessments correlated to the state of alertness) to the different measured parameters | At enrollment visit |
| D009422 | Nervous System Diseases |
| D001523 | Mental Disorders |