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The overall purpose of this study is to employ a pragmatic, multidimensional assessment of hypersomnolence that "piggybacks" on routine clinical care in patients with suspected disorders of central nervous system (CNS) hypersomnia, to determine whether these additional objective and subjective assessments are useful in the diagnosis and management of these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Hypersomnolence | Patients referred for polysomnography and multiple sleep latency test |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pupillometry | Device | Measures pupillary dynamics in darkness and light conditions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of Patients Categorized with Hypersomnolence | Multiple measurements will be aggregated to arrive at the primary outcome of proportion of patients categorized as having hypersomnolence using either standard assessments or standard assessments plus additional novel hypersomnolence measures of pupillometry, psychomotor vigilance task, and auditory evoked potentials. Proportion of patients with hypersomnolence using standard measures will be calculated as number of patients with mean sleep latency (MSL) on multiple sleep latency test (MSLT) <8 minutes divided by total number of patients. Proportion of patients categorized as having hypersomnolence with additional novel hypersomnolence measures will be calculated as the number of patients with MSL<8 minutes, and/or pupillary unrest index (PUI) >8.9 on pupillometry, and/or PVT lapses >3, and/or P300 delay/sleep negativity during auditory evoked potentials divided by total number of patients. | 2 Years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients referred for polysomnography and multiple sleep latency test at the University of Wisconsin-Madison
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| Name | Affiliation | Role |
|---|---|---|
| David T Plante, MD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin-Madison, Department of Psychiatry | Madison | Wisconsin | 53719 | United States |
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| ID | Term |
|---|---|
| D006970 | Disorders of Excessive Somnolence |
| ID | Term |
|---|---|
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D005072 | Evoked Potentials, Auditory |
| ID | Term |
|---|---|
| D005071 | Evoked Potentials |
| D000071080 | Cortical Excitability |
| D055724 | Electrophysiological Phenomena |
| D010829 | Physiological Phenomena |
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| Psychomotor Vigilance Task | Behavioral | Response time task measuring neurobehavioral alertness |
|
| Auditory Evoked Potential | Other | Measure of electroencephalographic response to standardized auditory tones |
|
| Hypersomnia Severity Index | Behavioral | Self-report measure of hypersomnolence |
|
| D001523 |
| Mental Disorders |
| D000084323 | Vestibulocochlear Physiological Phenomena |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |