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The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES with preeclampsia or eclampsia to analyze features of clinical imaging, disease severity and pregnancy outcomes during 2012 to 2021.Then, the investigators grouped all the patients into early onset group and late onset PE group according to gestational weeks to analyze differences of clinical imaging. Finally, the investigators grouped all the patients into good pregnancy outcomes group and poor pregnancy outcomes group according to diagnostic criteria, including the incidence of stillbirth and premature birth, to analyze differences of clinical imaging .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRES in PE or E | patients diagnosed with PRES in PE or E |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PRES in PE or E | Diagnostic Test | patients diagnosed with posterior reversible encephalopathy syndrome with preeclampsia or eclampsia |
|
| Measure | Description | Time Frame |
|---|---|---|
| features of clinical imaging | The imaging features were described by their location including frontal, parietal, occipital, temporal, cerebellum, basal ganglia, brain stem, deep white matter and callosum, and 1 point was recorded for each location involved. | Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment, mental disorders, and focal neurological deficits. |
| blood pressure(BP) | hypertension：≥140/90mmHg | The BP of patients was obtained immediately at the onset of symptoms. |
| biochemical parameters | The PRES patients may have a lower level of serum albumin (﹤35g/L) ,and have a higher level of lactic dehydrogenase (﹥380U/L). | Biochemical indicators were collected within 1 week of the hospital stay. |
| pregnancy outcomes | The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients. | The pregnancy outcomes will record immediately when the patients deliver. |
| pregnancy outcomes | The PRES patients may have longer time of hospitalization. | From day of admission until the day of discharge or date of death from any cause,whichever came first,assessed up to 1 year. |
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Inclusion Criteria:
Exclusion Criteria:
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pregnant woman diagnosed with PRES with preeclampsia or eclampsia
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou | 510150 | China |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 15, 2022 | |
| Unrelease | Mar 15, 2022 | |
| Release | Apr 6, 2022 | |
| Reset | Nov 8, 2022 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 15, 2022 | Mar 15, 2022 | |||
| Apr 6, 2022 |
| ID | Term |
|---|---|
| D054038 | Posterior Leukoencephalopathy Syndrome |
| D011225 | Pre-Eclampsia |
| D004461 | Eclampsia |
| ID | Term |
|---|---|
| D020343 | Hypertensive Encephalopathy |
| D019586 | Intracranial Hypertension |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D011312 | Pressure |
| ID | Term |
|---|---|
| D055595 | Mechanical Phenomena |
| D055585 | Physical Phenomena |
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| Nov 8, 2022 |
| D009422 | Nervous System Diseases |
| D056784 | Leukoencephalopathies |
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |