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The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.
This is a prospective study. The investigators divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . The general information(demographic data,blood pressure.etc.)and blood sample will be collected. Additionally,all patients receive neuroimaging examination(DTI,ASL,3D-TMI.etc.)and neuro-cognitive test(MMSE,MOCA,CFQ, etc.) to assess the cerebral white matter lesions and cognitive changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRES group | PE or E with PRES |
| |
| non-PRES group | PE or E without PRES |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| neuroimaging examination,neuro-cognitive test,blood pressure,blood sample | Biological | neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested |
| Measure | Description | Time Frame |
|---|---|---|
| neuroimaging examination | the degree of white matter lesions(0,normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema > cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema > cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost completely confluent; 5, involved regions are fully confluent and continuous, ventricular deformity due to the oedema).The value of fractional anisotropy(FA) in PRES group may higher than non- PRES group, and mean diffusivity (MD) in PRES group may lower than non- PRES group. | within 10 years after deliver |
| neuro-cognitive test of Mini-mental State Examination | the scores of Mini-mental State Examination,normal (27-30);mild (21-26); moderate (10-20); severe (0-9). | within 10 years after deliver |
| neuro-cognitive test of Montreal Cognitive Assessment | the scores of Montreal Cognitive Assessment,normal (≥26); abnormal (<26). | within 10 years after deliver |
| blood pressure and hypertension | Hypertension: blood pressure ≥140/90 mmHg | within 10 years after deliver |
| level of lactate dehydrogenase(LDH) | inflammatory: LDH>380U/L | within 10 years after deliver |
| level of LDL in blood | hyperlipidemia:LDL>3.12mmol/L | within 10 years after deliver |
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Inclusion Criteria:
Exclusion Criteria:
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We divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . the general information(demographic data,blood pressure.etc.)and blood sample will be collected.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dunjin Chen | Contact | 18928916722 | gzdrchen@gzhmu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou | 510150 | China |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D054038 | Posterior Leukoencephalopathy Syndrome |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D020343 | Hypertensive Encephalopathy |
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blood
| D019586 | Intracranial Hypertension |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D056784 | Leukoencephalopathies |