Intrathecal Atropine Versus Intravenous Ondasetron in Pos... | NCT05137288

NCT05137288

Protocol Section

Identification Module

Results Section

No data available

No data is available for this block.

Annotation Section

Annotation Module

Unposted Annotation

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Status Module

Sponsor/Collaborators Module

Oversight Module

Description Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
patients receiving intrathecal atropine	Active Comparator	Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% ) with morphine 250mic and atropine sulphate 100 micwith total volume = 2.5 ml .	Drug: Ondansetron , atropine and bupivacaine
patients receiving preoperative intravenous ondasetron	Active Comparator	Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% with 0.5 ml normal saline with morphine 250 mic ) with total volume = 2.5 ml with giving 4 mg IV ondansetron before anesthesia ( patients with body weight more than 80 Kg may need additional 4 mg IV ) .	Drug: Ondansetron , atropine and bupivacaine

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Ondansetron , atropine and bupivacaine	Drug	Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% ) with morphine 250mic and atropine sulphate 100 micwith total volume = 2.5 ml . Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% with 0.5 ml normal saline with morphine 250 mic ) with total volume = 2.5 ml with giving 4 mg IV ondansetron before anesthesia ( patients with body weight more than 80 Kg may need additional 4 mg IV ) .

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
frequency of attacks of postoperative nausea and vomiting	Intrathecal atropine versus preoperative intravenous ondasetron for prevention of postoperative nausea and vomiting due to intrathecal morphine	6-9 months

Eligibility Module

Contacts/Locations Module

Name	Role	Phone	Extension	Email
shehab m mohamed, resident	Contact	01147223196		shehabmahmoud@med.sohag.edu.eg
elhadad a mousa, professor	Contact

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
15102380	Background	Gybels J, Erdine S, Maeyaert J, Meyerson B, Winkelmuller W, Augustinsson L, Bonezzi C, Brasseur L, DeJongste M, Kupers R, Marchettini P, Muller-Schwefe G, Nitescu P, Plaghki L, Reig E, Spincemaille G, Thomson S, Tronnier V, Van Buyten JP. Neuromodulation of pain. A consensus statement prepared in Brussels 16-18 January 1998 by the following task force of the European Federation of IASP Chapters (EFIC). Eur J Pain. 1998;2(3):203-9. doi: 10.1016/s1090-3801(98)90016-7. No abstract available.
21730925

IPD Sharing Statement Module

Type	Date	Date Unknown
Release	Feb 9, 2023
Reset	Nov 20, 2023

Release Date	Unrelease Date	Unrelease Date Unknown	Reset Date	MCP Release Number
Feb 9, 2023			Nov 20, 2023

Intervention Browse Module

ID	Term
D007093	Imidazoles
D001393	Azoles
D006573	Heterocyclic Compounds, 1-Ring
D006571	Heterocyclic Compounds