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To search for a genetic marker of hemorrhagic stroke complicating severe eclampsia, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with hemorrhagic stroke and normal control will be performed.
Detailed Description:
Unrelated Korean subjects who have Spontaneous hemorrhagic stroke complicating severe eclampsia in pregnancy were recruited in the current study. Genotyping for various SNP associated due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with hemorrhagic stroke and normal control subjects free of hemorrhagic stroke
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group: | patients with hemorrhagic stroke complicating severe pre-eclampsia in pregnancy |
| |
| Control group | patients without hemorrhagic stroke complicating severe pre-eclampsia in pregnancy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SNP analysis of the DNA | Genetic | SNP analysis of the DNA obtained from peripheral blood sample |
|
| Measure | Description | Time Frame |
|---|---|---|
| genotyping for the SNP associated with hemorrhagic stroke complicating severe eclampsia in pregnancy | 1 year |
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Inclusion Criteria:
-patients with hemorrhagic stroke complicating severe eclampsia in pregnancy
Exclusion Criteria:
patients without hemorrhagic stroke complicating severe eclampsia in pregnancy
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patients with hemorrhagic stroke complicating severe eclampsia in pregnancy who visited Scientific Center for Obstetrics, Gynecology and Perinatology. Kazakhstan, Almaty
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| Name | Affiliation | Role |
|---|---|---|
| Aygul Terlikbayeva, PhD | JSC "Scientific center of obstetrics, gynecology and perinatology" | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital | Almaty | Kazakhstan |
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Blood
| ID | Term |
|---|---|
| D000083302 | Hemorrhagic Stroke |
| D004461 | Eclampsia |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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