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The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with LVR(left ventricular remodeling) | |||
| patients without LVR(left ventricular remodeling) |
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| Measure | Description | Time Frame |
|---|---|---|
| Delta-work efficiency by echocardiography | A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE. | 24-72 hours after PCI |
| Measure | Description | Time Frame |
|---|---|---|
| Global work index by echocardiography | Global work index (GWI) is classified as total work within the area of the LV pressure-strain loop calculated from mitral valve closure to mitral valve opening. | 24-72 hours, 3-month after PCI |
| Global constructive work by echocardiography |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with anterior STEMI who underwent primary PCI <12 hours after symptom onset were consecutive enrolled in our center.
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| Name | Affiliation | Role |
|---|---|---|
| Song Ding, MD,PHD | Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University | Shanghai | Shanghai Municipality | 200125 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35966524 | Derived | Wang W, Zhao H, Wan F, Shen XD, Ding S, Pu J. Inhomogeneous Distribution of Regional Myocardial Work Efficiency Predicts Early Left Ventricular Remodeling After Acute Anterior Myocardial Infarction Treated With Primary Percutaneous Intervention. Front Cardiovasc Med. 2022 Jul 27;9:922567. doi: 10.3389/fcvm.2022.922567. eCollection 2022. |
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| ID | Term |
|---|---|
| D020257 | Ventricular Remodeling |
| ID | Term |
|---|---|
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Global constructive work (GCW) was defined as work contributing to LV ejection performed during shortening in systole and work performed during lengthening in isovolumic relaxation. |
| 24-72 hours, 3-month after PCI |
| Global work efficiency by echocardiography | Global work efficiency (GWE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage. | 24-72 hours, 3-month after PCI |
| Work index-LAD | Work index in left anterior descending(LAD) territory. | 24-72 hours, 3-month after PCI |
| Constructive work-LAD | constructive work in left anterior descending(LAD) territory. | 24-72 hours, 3-month after PCI |
| Work efficiency-LAD | Work efficiency in left anterior descending(LAD) territory. | 24-72 hours, 3-month after PCI |