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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-A02277-34 | Other Identifier | N°ID-RCB |
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Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs.
The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spinal cord Tractography | Experimental | Healthy volunteer having the tractography exam |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spinal cord Tractography in order to differentiate spinal tracts. | Procedure | Spinal cord tractography using DTI MRI sequences of the brain and spinal cord, in order to differentiate tracts at the spinal cord level; and by performing a stitching process between Brain and Spinal cord DTI sequences. |
| Measure | Description | Time Frame |
|---|---|---|
| Spinal tracts differentiation and identification | Percentage of complete tracts identified among healthy volunteer | date of Tractography procedure (DTI MRI) |
| Measure | Description | Time Frame |
|---|---|---|
| Spinal cord Tracts Atlas | Elaboration of a tracts classification using a algorithm based on the type, the volume and the fraction of anisotropy and mean diffusivity of each tract | 12 months (end of recruitment and exams) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| DAULEAC Corentin, Dr | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dauleac Corentin | Bron | 69500 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39129322 | Background | Dauleac C, Mertens P, Frindel C, Jacquesson T, Cotton F. Atlas-guided brain projection tracts: From regions of interest to tractography 3D rendering. J Anat. 2025 May;246(5):732-744. doi: 10.1111/joa.14120. Epub 2024 Aug 11. |
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