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Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients.
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue, which is composed of adipose tissue deposited between the myocardium and the visceral layer of the pericardium. It is closely adjacent to the coronary arteries and myocardium. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients. This study intends to observe the relationship between epicardial fat thickness and left and right functions in patients with HFpEF, and evaluate whether epicardial fat thickness can be used as an indicator of left and right dysfunction.
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| Measure | Description | Time Frame |
|---|---|---|
| Epicardial Fat Tissue | Epicardial Fat Tissue by cardiac color Doppler ultrasound | On admission |
| Cardiac Function | Left ventricular diastolic function and right ventricular systolic function by cardiac color Doppler ultrasound | On admission |
| Composite Endpoint of Worsening Heart Failure Event and Cardiovascular Death | Composite Endpoint of Worsening Heart Failure Event and Cardiovascular Death | From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Worsening HF Event | Worsening Heart Failure Event | From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years |
| CV Death | Cardiovascular Death |
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Inclusion Criteria:
Diagnostic criteria including:
Exclusion Criteria:
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Heart failure patients with preserved ejection fraction (HFpEF)
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| Name | Affiliation | Role |
|---|---|---|
| Dongying Zhang, doctor | First Affiliated Hospital of Chongqing Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Chongqing Medical University | Chongqing | China |
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| From date of discharge until the date of death, whichever came first, assessed up to 10 years |
| All-cause Death | Death from any causes | From date of discharge until the date of death, whichever came first, assessed up to 10 years |