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| Name | Class |
|---|---|
| University Hospital, Caen | OTHER |
| University Hospital, Brest | OTHER |
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Normal pressure hydrocephalus (NPH) can cause a type of dementia. However, this type of dementia is the only one that is reversible. To treat this dementia it is necessary to evacuate the accumulation of CSF from the brain to another body cavity using a device called a shunt. But the implantation of this shunt is only effective when the cause of the pathology is an alteration of the normal circulation of the CSF. To diagnose these patients, morphological MRI and lumbar puncture are standard approaches used but remain perfectible in diagnostic terms.
The main objective is to build a new model of the interaction of intracranial pressures and fluids in order to obtain a new parameter allowing to obtain information on the cerebral biomechanics.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Flow MRI | Other | 4 flow acquisitions based on the 2D cine phase contrast sequence (present on all MRI systems) will be performed. This sequence requires a cardiac synchronization by a plethysmograph put on the patient's finger. 32 cardiac phases are reconstructed per acquisition. The processing of the flow MRIs and the analysis of the flow curves of the LCS and blood during the cardiac cycle will be performed using the Amiens software. Parameters measured via flow MRI are: - Cerebral vascular flow, intracranial LCS dynamic volume, extracranial LCS dynamic volume | ||
| PERFUSION TEST | Other | The test will be performed will include:
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| Measure | Description | Time Frame |
|---|---|---|
| Variation of number of MRICP parameters according of CSF accumulation | The MRICP parameter will combine the CSF pressure and CSF flows. MRICP parameter results of the interaction of intracranial pressures and fluids in order allowing to obtain information on the cerebral biomechanics. Accumulation of CSF from the brain to another body cavity is neccessary to be determined. | up to 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with suspected active hydrocephalus (HA) known as "normal pressure" and with Flow MRI and CSF infusion test.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens | Salouël | 80480 | France |
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| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
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| D001523 | Mental Disorders |