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| ID | Type | Description | Link |
|---|---|---|---|
| 2011-A01633-38 | Registry Identifier | RCB |
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Normal pressure hydrocephalus diagnosis based on quantitative study of cerebro-spinal fluid and blood flow by phase contrast magnetic resonance imaging.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Surgery | Experimental | Patients who will undergo flow imaging and neurosurgery (shunting). (25% of the studied population) |
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| Clinical follow-up | Experimental | Patients who will undergo flow imaging but not surgery (75% of the studied population) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Flow imaging | Other | Quantitative flow study was performed by 2D phase-contrast velocity-encoded cine MRI (repetition/echo time, 15/7 ms; field of view = 140 x 140 mm²; matrix size = 256 x 128, flip angle = 25 degrees,one excitation, slice thickness = 5 mm). Cerebrospinal fluid and blood flows are measured with a velocity-encoding value of 5-10 cm/s and 80 cm/s respectively. Peripheral gating was used to cover the entire cardiac cycle with retrospective cardiac synchronization of 32 quantitative flow-encoded images per cycle. Clinical examination consists in Larson's score and MMSE |
| Measure | Description | Time Frame |
|---|---|---|
| cerebrospinal fluid (CSF) stroke volume evolution other 6 months | Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution | Day 1 (baseline), Day 180 |
| Measure | Description | Time Frame |
|---|---|---|
| Blood flow analysis : evolution other 6 months | Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution. | Day 1 (baseline), Day 180 |
| Larson's score evolution over 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Olivier Balédent, PhD | CHU Amiens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Lille | Lille | Hauts-de-France | 59000 | France | ||
| CHU Amiens |
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| ID | Term |
|---|---|
| D006850 | Hydrocephalus, Normal Pressure |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D057446 | Hydrodynamics |
| D002560 | Cerebrovascular Circulation |
| ID | Term |
|---|---|
| D055585 | Physical Phenomena |
| D001775 | Blood Circulation |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
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|
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Record symptoms on walking, living conditions and urinary disorders |
| Day 1, Day 180 |
| Neuropsychological test evolution over 6 months | Consists in mini mental status evaluation (MMSE) for cognitive evaluation | Day1, Day 180 |
| Blood flow analysis : evolution other one year | Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution. | Day 1 (baseline) and Day 365 |
| Larson's score evolution over one year | Record symptoms on walking, living conditions and urinary disorders | Day 1 and Day 365 |
| Neuropsychological test evolution over one year | Consists in mini mental status evaluation (MMSE) for cognitive evaluation | Day1, Day 365 |
| cerebrospinal fluid (CSF) stroke volume evolution other one year | Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution | Day1 (baseline), Day 365 |
| Amiens |
| Picardie |
| 80054 |
| France |
| D019965 |
| Neurocognitive Disorders |
| D001523 | Mental Disorders |