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| ID | Type | Description | Link |
|---|---|---|---|
| 2006/0023 | Registry Identifier | DGS |
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The idea is to assess the predictive value of flow magnetic resonance imaging (flow MRI) for patient suffering normal pressure hydrocephalus (NPH) planned for surgery. By now, the depletive lumbar puncture is the best test assessing the efficacy of a forthcoming surgery. The idea is to demonstrate that flow MRI can be as effective as lumbar puncture in term of predictive value of surgery response.
In that way, cerebrospinal fluid (CSF) dynamics are evaluated by a single non invasive examination. CSF flow is measured at the Sylvius' aqueduct, cervical, arachnoid space and 4th ventricle levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal pressure hydrocephalus | Experimental | Hydrocephalus patients planned for shunting surgery. They will undergo clinical and imaging examinations at day 1, 3 months and 1 year after their surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| clinical and imaging examinations | Other | Quantitative CSF flow study was performed by 2D phase-contrast velocity-encoded cine MRI (repetition/echo time, 15/7 ms; field of view = 140 x 140 mm²; matrix size = 256 x 128, flip angle = 25 degrees,one excitation, slice thickness = 5 mm). Cerebrospinal fluid flow was measured with a velocity-encoding value of 10-20 cm/s. Peripheral gating was used to cover the entire cardiac cycle with retrospective cardiac synchronization of 32 quantitative flow-encoded images per cycle. Clinical examination consists in neuropsychological assessment (including mini mental state examination test and Bradley's scale) as well as Hakim's triad evaluation |
| Measure | Description | Time Frame |
|---|---|---|
| CSF stroke volume | Measurement of CSF stroke volume via flow MRI at the Sylvius' aqueduct level | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Hakim's triad evaluation | Assessment of the signs of normal pressure hydrocephalus | Day 1 |
| Hakim's triad evaluation | Assessment of the signs of normal pressure hydrocephalus (follow-up) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens | Amiens | Picardie | 80054 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20097391 | Result | Mouton Paradot G, Baledent O, Sallioux G, Lehmann P, Gondry-Jouet C, Le Gars D. [Contribution of phase-contrast MRI to the management of patients with normal pressure hydrocephalus: Can it predict response to shunting?]. Neurochirurgie. 2010 Feb;56(1):50-4. doi: 10.1016/j.neuchi.2009.12.007. Epub 2010 Jan 25. French. |
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| ID | Term |
|---|---|
| D006850 | Hydrocephalus, Normal Pressure |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D006849 | Hydrocephalus |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D057446 | Hydrodynamics |
| ID | Term |
|---|---|
| D055585 | Physical Phenomena |
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|
|
| Day 90 |
| Hakim's triad evaluation | Assessment of the signs of normal pressure hydrocephalus (follow-up) | Day 365 |
| Neuropsychological test | classical neuropsychological assessment (including mini mental status evaluation) | Day 1 |
| Neuropsychological test | classical neuropsychological assessment (including mini mental status evaluation) (follow up) | Day 90 |
| Neuropsychological test | classical neuropsychological assessment (including mini mental status evaluation) (follow up) | Day 365 |
| CSF stroke volume | Measurement of CSF stroke volume by flow MRI at the Sylvius' aqueduct level (follow-up) | Day 60 |
| CSF stroke volume | Measurement of CSF stroke volume by flow MRI at the Sylvius' aqueduct level (follow-up) | Day 365 |
| D019965 |
| Neurocognitive Disorders |
| D001523 | Mental Disorders |