Verification of Saliva MMP-1 as a Diagnostic Marker of Oral Cavity Cancer

Verification of Saliva MMP-1 as a Strong Diagnostic Marker of Oral Cavity Cancer

The study is designed to measure salivary matrix metalloproteinase-1 (MMP-1) using the enzyme-linked immunosorbent assay (ELISA) we developed previously in patients with oral potentially malignant disorders (OPMD), oral squamous cell carcinoma (OSCC), and healthy participants. The purpose of this study is to evaluate the potential of the newly developed salivary MMP-1 ELISA as an adjunctive tool to aid in diagnosis of OSCC.

Inclusion Criteria:

• Group OSCC: patients with lesions of OSCC
• Group OPMD: patients with lesions of OPMD
• Group HC: healthy subjects who are not suffering from any oral lesions and having behaviors of smoking, and/or betel nut chewing

Exclusion Criteria:

• Subjects having personal history of other cancers or severe diseases