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The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.
The aim of the study is to demonstrate any differences in myocardial structure and function using multiparametric cardiac MRI in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay and subsequent convalescence compared to a control group with intensive care stay but without kidney injury. Furthermore, the correlation between clinical disease severity and cardiac involvement will be investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intensiv care patients after acute kidney injury | Patients with condition after intensive care stay and acute kidney injury and subsequent convalescence (without preexisting underlying cardiac disease or other disease with potential cardiac involvement). |
| |
| Intensiv care patients without kidney injury | Patients with condition after intensive care stay and subsequent convalescence (without kidney injury and preexisting underlying cardiac disease or other disease with potential cardiac involvement). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac magnetic resonance scan | Diagnostic Test | Multiparametric cardiac magnetic resonance, including functional and structural parameter |
|
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial T1 relaxation time | T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in [ms]. | Measurement will be performed within 2 weeks after MRI scan. |
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial T2 relaxation time | T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in [ms]. | Measurement will be performed within 2 weeks after MRI scan. |
| Myocardial ECV |
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Inclusion criteria:
Exclusion criteria:
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Patients with convalescence after acute renal failure who were/are treated in the Department of Anesthesiology and Intensive Care Medicine of the University Hospital Bonn are included.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Julian A Luetkens, PD Dr. med. | Contact | +49 228 287-15960 | julian.luetkens@ukbonn.de | |
| Alexander Isaak, PD Dr. med. | Contact | +49 228 287-15960 | alexander.isaak@ukbonn.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology | Recruiting | Bonn | North Rhine-Westphalia | 53127 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37119085 | Derived | Isaak A, Pomareda I, Mesropyan N, Kravchenko D, Endler C, Bischoff L, Pieper CC, Kuetting D, Attenberger U, Zimmer S, Putensen C, Schewe JC, Kreyer S, Luetkens JA. Cardiovascular Magnetic Resonance in Survivors of Critical Illness: Cardiac Abnormalities Are Associated With Acute Kidney Injury. J Am Heart Assoc. 2023 May 2;12(9):e029492. doi: 10.1161/JAHA.123.029492. Epub 2023 Apr 29. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D059347 | Cardio-Renal Syndrome |
| D009202 | Cardiomyopathies |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in [%]. |
| Measurement will be performed within 2 weeks after MRI scan. |
| Myocardial strain | Cardiac magnetic resonance feature-tracking will be used to asses left ventricular longitudinal, circumferential and radial strain. | Measurement will be performed within 2 weeks after MRI scan. |
| University Hospital Bonn, Department of Anesthesiology and Intensive Care Medicine | Recruiting | Bonn | North Rhine-Westphalia | 53127 | Germany |
|
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D006333 | Heart Failure |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |