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| Name | Class |
|---|---|
| Cairo University | OTHER |
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Studying the effects of both inhalational anesthetics desflurane and sevoflurane on hepatic integrity and renal function, guided by recent blood and urine biomarkers in patients undergoing laparoscopic cholecystectomy surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sevoflurane | This group will receive sevoflurane as the maintenance inhalational anesthetic. |
| |
| Desflurane | This group will receive desflurane as the maintenance inhalational anesthetic. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neutrophil Gelatinase-Associated Lipocalin (NGAL) | Diagnostic Test | The evaluation of inhalational anesthetics (desflurane and sevoflurane) on NGAL levels in laparoscopic cholecystectomy patients. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum Neutrophil gelatinase-associated lipocalin (NGAL) | Renal Biomarker | a change from baseline NGAL serum level at 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum Arginase | Hepatic biomarker | Baseline, first hour, six hours, after 24 hours |
| Change in serum Cystatin-c | Hepatic biomarker |
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Inclusion Criteria:
Exclusion Criteria:
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After informed written consents have been taken, this study will be conducted on 70 patients scheduled for laparoscopic cholecystectomy. The patients will be randomly allocated into two groups (a desflurane (D) group and a sevoflurane (S) group) using a sealed envelope technique for each group.
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| Name | Affiliation | Role |
|---|---|---|
| Khalda G Radwan, MD | Theodor Bilharz Rsearch Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Theodor Bilharz Research Institute | Cairo | Egypt |
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077335 | Desflurane |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D005019 | Ethyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
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| Desflurane | Drug | Desflurane |
|
| Sevoflurane | Drug | Sevoflurane |
|
| Baseline, first hour, six hours, after 24 hours |
| Change in urine Netrin-1 | Renal biomarker | Baseline, first hour, six hours, after 24 hours |
| Change in urine Kidney Injury Molecule | Renal biomarker | Baseline, first hour, six hours, after 24 hours |
| Change in urine Interleukin-18 | cytokines | Baseline, first hour, six hours, after 24 hours |
| Change in urine Alpha-Glutathione S-Transferase | Liver biomarker | Baseline, first hour, six hours, after 24 hours |
| D006845 |
| Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |