Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy

Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial

This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).

Inclusion Criteria:

• Adults aged 18-65 years

ASA Physical Status I-II

Scheduled for elective laparoscopic cholecystectomy

Able to provide written informed consent

Exclusion Criteria:

Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane)

Severe chronic obstructive pulmonary disease (COPD)

Uncontrolled bronchial asthma

Decompensated heart failure (NYHA Class III-IV)

History of prior lung surgery

Morbid obesity (BMI > 35 kg/m²)

Pregnancy

Refusal to participate or inability to provide informed consent

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