Topo-pachimetric Accelerated Epi-On Cross-linking Compared to Dresden Protocol Using Riboflavin With Vitamin E TPGS

Topo-pachimetric Accelerated Epi-On Cross-linking Compared to Dresden Protocol Using Riboflavin With Vitamin E TPGS: Results of a 2-year Randomized Study

In the present study the investigators compare the clinical outcome corneal cross linking with either the stand-ard Dresden (sCXL) or the accelerated custom-fast (aCFXL) ultraviolet A irradiation protocol using riboflavin-D-α-Tocopheryl polyethyleneglycol1000 succinate for progressive keratoconus.

Inclusion Criteria:

• documented progressive keratoconus
• changes in uncorrected distance visual acuity (UDVA) above 1.00 D
• Corrected distance visual acuity (BCVA) above 1.00 D
• spherical equivalent greater than 0.50 D

Exclusion Criteria:

• Corneal pachymetry of less than 400 µm
• less than 2000 cells/cm2,
• corneal scarring,
• nystagmus or any motility disorder that prevented a fixed gaze during the examination
• Current contact lens use