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The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Accelerated | Active Comparator | Treatment with 0.1% riboflavin eye drops and 9 mW/cm2 UVA light for 10 minutes |
|
| Standard | Active Comparator | Treatment with 0.1% riboflavin eye drops and 3 mW/cm2 UVA light for 30 minutes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| riboflavin 0.1% | Combination Product | Use of riboflavin 0.1% eye drops and 9 mW/cm2 UVA light for 10 minutes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in maximum keratometry | assessed by corneal tomography | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in corrected distance visual acuity | assessed with Snellen chart | 6 months |
| Change in uncorrected distance visual acuity | assessed with Snellen chart |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marianne Price, PhD | Contact | 317-814-2990 | mprice@cornea.org |
| Name | Affiliation | Role |
|---|---|---|
| Francis W Price, Jr., MD | Price Vision Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Price Vision Group | Recruiting | Indianapolis | Indiana | 46260 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29203068 | Background | Price MO, Fairchild K, Feng MT, Price FW Jr. Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia. Ophthalmology. 2018 Apr;125(4):505-511. doi: 10.1016/j.ophtha.2017.10.034. Epub 2017 Dec 2. | |
| 29889294 | Background | Lautert J, Doshi D, Price FW Jr, Price MO. Corneal Epithelial Remodeling After Standard Epithelium-off Corneal Cross-linking in Keratoconic Eyes. J Refract Surg. 2018 Jun 1;34(6):408-412. doi: 10.3928/1081597X-20180402-03. |
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| ID | Term |
|---|---|
| D007640 | Keratoconus |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| Riboflavin 0.1% | Combination Product | Use of riboflavin 0.1% eye drops and 3 mW/cm2 UVA light for 30 minutes |
|
| 6 months |
| 29605283 | Background | Price MO, Feng MT, Price FW Jr. Patient satisfaction with epithelium-off corneal crosslinking. J Cataract Refract Surg. 2018 Mar;44(3):323-328. doi: 10.1016/j.jcrs.2017.12.023. Epub 2018 Mar 28. |