Accelerated Corneal Cross-linking With Different Riboflavin Solutions

Effect-evaluation of an Accelerated Corneal Cross-linking Protocol With Different Riboflavin Solutions

Following the Bunsen-Roscoe law, accelerated cross-linking protocols with higher irradiation intensities and shorter irradiation times have been introduced. In addition, new riboflavin solutions with HPMC (hydroxylpropyl methylcellulose) instead of dextran found its way into CXL-treatment. The aim of this trial is to evaluate clinical outcomes in an accelerated corneal collagen cross-linking protocol with different riboflavin solutions.

Inclusion Criteria:

• Progressive Keratoconus
• Indication for treatment
• Preoperative Pachymetry > 400

Exclusion Criteria:

• Pregnancy
• Re-CXL
• Keratitis
• Other visual acuity limiting eye diseases than corneal ectatic diseases