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In this research project, the effect of different polyphenol-containing beverages with varying alcohol content of < 0.4 vol% on immune function as well as muscular growth factors will be investigated
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| non-alcoholic Pilsner | Experimental | 1 L non-alcoholic Pilsner per day for 2 weeks |
|
| non-alcoholic wheat beer | Experimental | 1 L non-alcoholic wheat beer per day for 2 weeks |
|
| apple spritzer | Active Comparator | 1 L apple spritzer per day for 2 weeks |
|
| lemonade | Placebo Comparator | 1 L lemonade per day for 2 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-alcoholic Pilsner | Other | intake of 1 L non-alcoholic Pilsner per day for 2 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| white blood cells | white blood cell count | before beverage intake |
| white blood cells | white blood cell count | 60 minutes after intake |
| white blood cells | white blood cell count | 120 minutes after intake |
| inflammatory markers in the blood | IL-6, TNF- α, hs-CRP | before beverage intake |
| inflammatory markers in the blood | IL-6, TNF- α, hs-CRP | 60 minutes after intake |
| inflammatory markers in the blood | IL-6, TNF- α, hs-CRP | 120 minutes after intake |
| blood alcohol | blood alcohol level | before beverage intake |
| blood alcohol | blood alcohol level | 60 minutes after intake |
| blood alcohol | blood alcohol level | 120 minutes after intake |
| Measure | Description | Time Frame |
|---|---|---|
| dietary habit | 3 day food diary | before beverage intake and day 12-14 of beverage intake |
| dietary habit | 3 day food diary | day 12-14 of beverage intake |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Johannes Scherr, Prof | Balgrist University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Balgrist University Hospital | Zurich | 8008 | Switzerland |
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| ID | Term |
|---|---|
| D000073923 | Food Intolerance |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| non-alcoholic wheat beer | Other | intake of 1 L non-alcoholic wheat beer per day for 2 weeks |
|
| apple spritzer | Other | intake of 1 L apple spritzer per day for 2 weeks |
|
| lemonade | Other | intake of 1 L lemonade per day for 2 weeks |
|
| white blood cells | white blood cell count | after 14 days of daily intake |
| inflammatory markers in the blood | IL-6, TNF- α, hs-CRP | after 14 days of daily intake |
| blood alcohol | blood alcohol level | after 14 days of daily intake |
| polyphenol in the urine | polyphenol level in the urine | before beverage intake |
| polyphenol in the urine | polyphenol level in the urine | 120 minutes after intake |
| polyphenol in the urine | polyphenol level in the urine | after 14 days of daily intake |
| physical activity | Global Physical Activity Questionnaire (allows to calculate metabolic equivalents to express the intensity of physical activities | before beverage intake |
| physical activity | Global Physical Activity Questionnaire (allows to calculate metabolic equivalents to express the intensity of physical activities | day 14 of beverage intake |