Function of Circulating Exosomes in Sepsis-induced Immunosuppression

Function of Circulating Exosomes in Sepsis-induced Immunosuppression

This is a single-center prospective bio-specimen analysis and observational study aiming to define immune pathways disrupted in bacterial sepsis and to identify clinically useful biomarkers of immune status.

Inclusion Criteria:

• ≥ 50 years with ≥ 2 chronic comorbidities
• Highly suspected bacterial infection based on clinical or radiologic evidence
• ≥ 2 systemic inflammatory response syndrome (SIRS) criteria
• Actual/anticipated admission to intensive care unit (ICU)
• Anticipated length of hospital stay ≥ 5 days

Exclusion Criteria:

• Pregnancy
• Underlying immunosuppression (solid organ transplant, hematopoietic stem cell transplant, neutropenia, HIV infection, long-term corticosteroid use (≥ 20 mg prednisone equivalents for ≥ 14 days), immunosuppressants, radiation, chemotherapy, immune-modifying biologics, viral hepatitis, or systemic autoimmune diseases)
• Current immunotherapy use
• Confirmed COVID-19 infection