Immune Homeostasis in Sepsis and Septic Shock

Immune Homeostasis in Patients With Sepsis and Septic Shock: a Single Center Observational Study

Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.

Inclusion Criteria:

• sepsis/septic shock (SEPSIS-3)
• age ≥18
• informed consent
• inclusion within first 24hrs after development/diagnosis of septic shock

Exclusion Criteria:

• disagreement of the patient or legal representative with the entry into the study
• patients with primary or secondary immunodeficiency
• presence of active haematological malignancy or an active non-haematological malignancy