Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sepsis/septic shock | target population |
| |
| non-septic critically ill | demographically-matched control group |
| |
| healthy control | control group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcriptomics | Other | transcriptomics |
|
| Measure | Description | Time Frame |
|---|---|---|
| Immune response description - flow cytometry | Detailed description of immune response analyzed by mean of flow cytometry | 2024 - 2026 |
| Immune response description - transcriptomics | Detailed description of immune response analyzed by mean of transcriptomic analysis | 2024 - 2026 |
| Immune response description - ELISA | Detailed description of immune response analyzed by mean of ELISA | 2024 - 2026 |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic "immune status" panel | Diagnostic tool for immune status assessment | 2026 - 2028 |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
sepsis/septic shock according SEPSIS-3 definition
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thomas Karvunidis, MD, Ph.D. | Contact | +420 377 103 173 | karvunidist@fnplzen.cz | |
| Marcela Královcová, MD | Contact | +420 377 103 173 | kralovcovam@fnplzen.cz |
| Name | Affiliation | Role |
|---|---|---|
| Thomas Karvunidis, MD, PhD | Carles University Teaching Hospital and Faculty of Medicine in Pilsen, Pilsen, Czech Republic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical ICU, 1st Dept. of Internal Medicine, Teaching Hospital in Pilsen | Recruiting | Pilsen | Česká Republika | 330 01 | Czechia |
Not provided
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007153 | Immunologic Deficiency Syndromes |
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
Not provided
Not provided
| ID | Term |
|---|---|
| D020869 | Gene Expression Profiling |
| D005434 | Flow Cytometry |
| D016207 | Cytokines |
| ID | Term |
|---|---|
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D002469 | Cell Separation |
| D003584 | Cytological Techniques |
Not provided
Not provided
Not provided
Not provided
Not provided
peripheral blood
| flow-cytometry | Other | peripheral blood myeloid cells and lymphocytes flow-cytometry |
|
| cytokines | Other | peripheral blood cytokine analysis |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D007154 | Immune System Diseases |
| D012769 | Shock |
| D019411 |
| Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D003592 | Cytophotometry |
| D005470 | Fluorometry |
| D008163 | Luminescent Measurements |
| D010783 | Photometry |
| D002623 | Chemistry Techniques, Analytical |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |