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Phosphatidylserine is a phospholipid found in high concentrations in the brain and nervous tissues along with naturally occurring in many foods. It has been extensively studied for its effects on improving cognitive function, learning, memory and alleviating stress. However, more recently it has been proposed that phosphatidylserine could improve exercise capacity. The mechanisms of proposed action are difficult to distinguish because of the limited research and therefore the purpose of this study is to identify the proposed mechanism of action of phosphatidylserine supplementation and to establish whether these mechanisms will have an effect on time trial performance in trained male cyclists.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phosphatidylserine, 800 mg per day, 10 days | Experimental |
| |
| Maltodextrin, 800 mg per day, 10 days | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phosphatidylserine | Dietary Supplement | 800 mg per day for 10 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| 30 minute cycling time-trial power output on an electromagnetically-braked cycle ergometer | Mean power output | From baseline to 11 days post supplementation |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygen consumption at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using an online breath-by-breath gas analyser | From baseline to 11 days post supplementation |
| Respiratory exchange ratio at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer |
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Inclusion Criteria:
Exclusion Criteria:
All participants must be trained male cyclists
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mark Glaister, PhD | Contact | 02082404012 | mark.glaister@stmarys.ac.uk |
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| ID | Term |
|---|---|
| D010718 | Phosphatidylserines |
| ID | Term |
|---|---|
| D020404 | Glycerophospholipids |
| D010712 | Phosphatidic Acids |
| D005994 | Glycerophosphates |
| D010743 | Phospholipids |
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Participants matched on cycling time-trial performance and then randomly assigned to treatment or placebo groups
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The experiment will follow a double-blind design where all participants and investigators will be blinded to the treatments given.
Evaluated using an online breath-by-breath gas analyser |
| From baseline to 11 days post supplementation |
| Breathing frequency at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using an online breath-by-breath gas analyser | From baseline to 11 days post supplementation |
| Minute ventilation at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using an online breath-by-breath gas analyser | From baseline to 11 days post supplementation |
| Blood lactate concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Obtained via capillary puncture and analysed using an automated analyser | From baseline to 11 days post supplementation |
| Blood glucose concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Obtained via capillary puncture and analysed using an automated analyser | From baseline to 11 days post supplementation |
| Rating of perceived exertion at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using a 15-point (6-20) scale | From baseline to 11 days post supplementation |
| Heart rate at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer | Evaluated using a heart rate monitor | From baseline to 11 days post supplementation |
| D008563 |
| Membrane Lipids |
| D008055 | Lipids |