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IVF is one of the most successful treatment of fertility, (1) however, several IVF cycles fail to achieve pregnancy (2).failure defined as three or more failed attempts of ICSI (3). Implantation failure is a complex in nature, may be due to structural or functional causes (3, 4).
that previously undiagnosed, misinterpreted initial diagnoses, or subtle newly added intrauterine abnormalities may be a significant cause of IVF failure (5, 6), studies say that intra-uterine pathologies represent 40-50 % of causes of ICSI failure (7, 8), hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum, or intrauterine adhesions could increase the pregnancy rate (9). so, Evaluation of the uterine cavity may become a routine investigation before assisted reproductive technology(ART) procedures (10).
In this study, we evaluate the relationship between the different uterine and cervical pathologies and decreased live birth rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Women with hysteroscopically or ultrasonographic detected uterine anomalies(adenomyosis,fibroid) intracavitary lesions ( like polyp, adhesion or septum) and those with detected endometrial abnormalities (like hypervascularization,pale endometrium) ,cervical lesion and cervical canal lesion or pelvic lesion |
| |
| Group B | Matched women (eg. Age,parity, BMI, ovarian reserve….) with no uterine or ovarian abnormalities assessed by hysteroscopy or ultrasonography. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IVF | Procedure | In vitro fertilization |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy rate | Pregnancy rate with IVF/ICSI with uterine lesions | Baseline |
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Inclusion Criteria:
Women between 18 and 38 years old.
Exclusion Criteria:
Refusal to join the study.
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Women between 18 and 38 years old.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Khaled Mostafa, Rsedent.dr | Contact | 0201140465869 | khaledmostafa849@yahoo.com | |
| Momen Kamel, Prof.dr | Contact | 0201000328901 | Momen_k2000@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Momen Kamel, Prof.dr | Assiut University | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16905025 | Background | Rai R, Regan L. Recurrent miscarriage. Lancet. 2006 Aug 12;368(9535):601-11. doi: 10.1016/S0140-6736(06)69204-0. | |
| 1426335 | Background | Dicker D, Ashkenazi J, Feldberg D, Farhi J, Shalev J, Ben-Rafael Z. The value of repeat hysteroscopic evaluation in patients with failed in vitro fertilization transfer cycles. Fertil Steril. 1992 Oct;58(4):833-5. doi: 10.1016/s0015-0282(16)55338-2. |
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| 15731311 | Background | Levi Setti PE, Colombo GV, Savasi V, Bulletti C, Albani E, Ferrazzi E. Implantation failure in assisted reproduction technology and a critical approach to treatment. Ann N Y Acad Sci. 2004 Dec;1034:184-99. doi: 10.1196/annals.1335.021. |