Vitamin D Supplementation on Outcome and Disease Activity.

Vitamin D Supplementation on Outcome and Disease Activity in Rheumatoid Arthritis Patients At Rajavithi Hospital : a Randomized Clinical Trial

To study efficacy of Vitamin D on outcome and disease activity ; DAS28-ESR in Rheumatoid arthritis patients at Rajavithi hospital .

Inclusion Criteria:

• Age > 18 yrs old
• RA diagnosed by ACR/EULAR 2010
• low to moderate disease activity
• on stable NSAIDs and DMARDs for at least 1 month
• Received Prednisolone less than or equal to 7.5 mg/day
• serum calcium, phosphorus and ALP are within normal limit.

Exclusion Criteria:

• Chronic kidney disease stage 3 or higher
• History of TB
• History of Chronic liver disease
• Pregnancy or breast-feeding
• adjustment of immuno-suppressive drugs, steroid
• other connective tissue disease
• Vitamin D allergy
• received other drugs which have vitamin D component
• serum Vitamin D less than 10 ng/mL