Effect of Vitamin D Supplement on Disease Activity in SLE

The Effect of Vitamin D Supplementation on Disease Activity of Systemic Lupus Erythematosus Patients: A Randomized Clinical Trial in Rajavithi Hospital

To study the effect of vitamin D supplementation on disease activity of SLE ( SLEDAI-2K ) and IL-6 level

Inclusion Criteria:

• Age > 18 year-old
• SLE classified by revised ACR criteria, SLICC 2012 criteria
• SLE patients who have mild to moderate disease activity ( clinical SLEDAI-2K 3-10 ) and has vitamin D level < 40 ng/ml
• currently treated with stable dose of 1 or more of the following background medication : NSAIDs, anti-malarial, MMF, Azathioprine, methotrexate, cyclosporin for at least 1 month, corticosteroid </= 20 mg/d of prednisolone or equivalent dose for at least 2 weeks
• received calciferol 20,000 IU/wk (1 cap) at least 12 weeks

Exclusion Criteria:

• patients with chronic liver disease, CKD stage 3, bed ridden, malignancy
• patients who received drug that interfere with vitamin D metabolism
• poor drug compliance
• overlap with other connective tissue disease or a diagnosis of MCTD
• hx of vitamin D allergy
• hx on MTV or other supplementation