Effect of Vitamin D Supplement on Disease Activity in SLE | NCT05260255 | Trialant

Effect of Vitamin D Supplement on Disease Activity in SLE | NCT05260255 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
vitamin D supplementation	Experimental	add on vitamin D2 ( calciferol ) 40,000 IU/wk for 12 weeks	Drug: vitamin D2 ( calciferol )
placebo	Placebo Comparator	add on placebo for 12 weeks	Drug: Placebo

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
To examine the effect of vitamin D supplementation on SLE disease activity	Study the SLE disease activity by SLEDAI-2K in relation with vitamin D levels	12 weeks

Secondary Outcomes

Measure	Description	Time Frame
To examine the effect of vitamin D supplementation on IL-6 level	monitor serum vitamin D before and after intervention	12 weeks
To determine whether IL-6 can early detection in SLE disease flare

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
33084768	Result	Ding J, Su S, You T, Xia T, Lin X, Chen Z, Zhang L. Serum interleukin-6 level is correlated with the disease activity of systemic lupus erythematosus: a meta-analysis. Clinics (Sao Paulo). 2020 Oct 19;75:e1801. doi: 10.6061/clinics/2020/e1801. eCollection 2020.
29280010	Result	Hassanalilou T, Khalili L, Ghavamzadeh S, Shokri A, Payahoo L, Bishak YK. Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation. Auto Immun Highlights. 2017 Dec 26;9(1):1. doi: 10.1007/s13317-017-0101-x.

Condition Browse Module

Intervention Browse Module