To investigate the migraine inducing effect of levcromakalim in patients with migraine with aura.

Inclusion Criteria:

• Migraine with aura patients of both sexes.
• 18-70 years.
• 50-100 kg.

Exclusion Criteria:

• Headache less than 48 hours before the tests start
• Daily consumption of drugs of any kind that investigator deems might affect study results or safety.
• Pregnant or nursing women.
• Cardiovascular disease of any kind, including cerebrovascular diseases.
• Tension type headache (TTH) according to International Classification of Headache Disorders version 3 more than 5 times a month on average during the past year
• Known cluster headache according to International Classification of Headache Disorders version 3.
• Psychiatric disorder
• Smoking or abuse of drugs or alcohol
• Hypertension (systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 mmHg) on day of inclusion.
• Hypotension (systolic blood pressure <90 mmHg and/or diastolic blood pressure <50 mmHg) on day of inclusion.