Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura

Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura

To investigate the migraine inducing effect of levcromakalim in patients with migraine with aura.

Inclusion Criteria:

• Migraine with aura patients of both sexes.
• 18-70 years.
• 50-100 kg.

Exclusion Criteria:

• Headache less than 48 hours before the tests start
• Daily consumption of drugs of any kind that investigator deems might affect study results or safety.
• Pregnant or nursing women.
• Cardiovascular disease of any kind, including cerebrovascular diseases.
• Tension type headache (TTH) according to International Classification of Headache Disorders version 3 more than 5 times a month on average during the past year
• Known cluster headache according to International Classification of Headache Disorders version 3.
• Psychiatric disorder
• Smoking or abuse of drugs or alcohol
• Hypertension (systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 mmHg) on day of inclusion.
• Hypotension (systolic blood pressure <90 mmHg and/or diastolic blood pressure <50 mmHg) on day of inclusion.