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To investigate the role of KATP channels in migraine with aura patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Levcromakalim | Active Comparator |
| |
| Saline | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levcromakalim | Drug | To investigate the role of levcromakalim compared with placebo in migraine with aura patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Headache | Occurrence of headache | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline |
| Migraine | Occurrence of migraine | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline |
| Aura | Occurrence of aura | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline |
| Measure | Description | Time Frame |
|---|---|---|
| The area under the curve (AUC) for headache | Headache intensity | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline |
| Family history |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Messoud Ashina | Danish Headache Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish headache center | Glostrup Municipality | 2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33768245 | Derived | Al-Karagholi MA, Ghanizada H, Nielsen CAW, Hougaard A, Ashina M. Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain. 2021 Sep 4;144(8):2322-2332. doi: 10.1093/brain/awab136. |
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| ID | Term |
|---|---|
| D006261 | Headache |
| D008881 | Migraine Disorders |
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D019806 | Cromakalim |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Saline | Drug | To investigate the role of levcromakalim compared with placebo in migraine with aura patients |
|
Direct interview with the 1 st degree family memeber for included patients according to international classification of headaches.
| After including the patients in the study. |
| Heart rate | Change in heart rate measured in Beats per minute (BPM) | Before (-10 min) and after infusion (+2 hours) of levcromakalim compared with before and after infusion of saline |
| Blood pressure | Change in blood pressure measured in mmHg | Before (-10 min) and after infusion (+2 hours) of levcromakalim compared with before and after infusion of saline |
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D001578 |
| Benzopyrans |
| D011714 | Pyrans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |