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To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Levcromakalim | Active Comparator |
| |
| Saline | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levcromakalim | Drug | To investigate the role of Levcromakalim on cerebral hemodynamic in migraine patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral hemodynamic | Change on Media cerebri arterie. | Before (-10 min) and after infusion (+2 hours) of levcromakalim compared with before and after infusion of saline |
| Headache | Occurrence of headache. | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline |
| Migraine attack | Occurrence | Before (-10 min) and after infusion (+12 hours) of levcromakalim compared with before and after infusion of saline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Messoud Ashina, Professor | DHC | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish headache center | Copenhagen | Glostrup | 2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31292608 | Derived | Al-Karagholi MA, Hansen JM, Guo S, Olesen J, Ashina M. Opening of ATP-sensitive potassium channels causes migraine attacks: a new target for the treatment of migraine. Brain. 2019 Sep 1;142(9):2644-2654. doi: 10.1093/brain/awz199. |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D019806 | Cromakalim |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Saline | Drug | To investigate the role of levcromakalim compared with saline cerebral hemodynamic in migraine patients. |
|
| D009422 | Nervous System Diseases |
| D001578 |
| Benzopyrans |
| D011714 | Pyrans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |