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This study is to investigate the effect of transcranial direct current stimulation (tDCS) simulation on motor learning to stroke patients compared to sham stimulation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real stimulation before motor learning training | Experimental | Patients receive five sessions of tDCS stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system immediately before sequential finger tapping task. |
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| Sham stimulation before motor learning training | Active Comparator | Patients receive five sessions of sham stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system immediately before sequential finger tapping task. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Direct Current Stimulation | Device | Transcranial direct current stimulation is a form of noninvasive neuromodulation that uses constant and low direct current delivered via electrodes on the scalp. |
| Measure | Description | Time Frame |
|---|---|---|
| Fugl-Meyer Assessment | The score is a stroke-specific, performance-based impairment index. The degree of impairment of upper and lower limbs is measured. | Baseline, immediately after five brain stimulation sessions |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in cortical activity using fNIRS signals during brain stimulation | Cortical activities before, during and after brain stimulation sessions are compared. | Baseline, during, immediately after five brain stimulation sessions |
| Changes in motor evoked potential |
| Measure | Description | Time Frame |
|---|---|---|
| Resting-state functional MRI | Before intervention, MRI is acquired to extract brain characteristics of stroke patients. | Baseline (Before stimulation sessions) |
| Changes in cortical activity using fNIRS signals. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | 06351 | South Korea |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Motor learning | Behavioral | Sequential finger tapping task training is applied to stroke patients. |
|
Resting motor threshold (rMT) and amplitude of motor evoked potential in first dorsal interosseous muscle are measured. These outcomes are measured by transcranial magnetic stimulation over the motor hotspot. The rMT is defined as the minimum stimulus intensity that produced a minimal motor evoked response at rest. The amplitude means peak to peak of the muscle response. |
| Baseline, immediately after five brain stimulation sessions |
| 9-hole pegboard test | The test is a standardized, quantitative assessment used to measure finger dexterity of a patient. | Baseline, immediately after five brain stimulation sessions |
| Grip & Tip pinch strength test | The test is to measure the maximum isometric strength of hand, forearm, and finger muscles. | Baseline, immediately after five brain stimulation sessions |
| Box & Block test | The test is used to measure the gross manual dexterity of a patient, or of a person using an upper limb prosthetic device. | Baseline, immediately after five brain stimulation sessions |
| Sequential Finger tapping test | Response time is measured during sequential finger tapping task. | Baseline, immediately after five brain stimulation sessions |
| Jebsen-Taylor hand function test | This test is a standardized and objective measure of fine and gross motor hand function using simulated activities of daily living (ADL). | Baseline, immediately after five brain stimulation sessions |
Before intervention, fNIRS image is acquired to extract cortical activation of stroke patients.
| Baseline (Before stimulation sessions) |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |