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The purpose of this study is to identify the characteristics of neural plasticity seen in stroke patients by measuring the changes in brain activity during stimulation using functional near-infrared spectroscopy (fNIRS) when applying transcranial direct current stimulation (tDCS) for the purpose of enhancing finger function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS stimulation group | Experimental | Patients receive four sessions of tDCS stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial direct current simulation | Device | Four sessions of stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in cortical activity using fNIRS signals during brain stimulation | Cortical activities before and after brain stimulation sessions are compared. | Baseline and about 10 days (immediately after brain stimulation sessions) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in motor evoked potential | Resting motor threshold (rMT) and amplitude of motor evoked potential in first dorsal interosseous muscle are measured. These outcomes are measured by transcranial magnetic stimulation over the motor hotspot. The rMT is defined as the minimum stimulus intensity that produced a minimal motor evoked response at rest. The amplitude means peak to peak of the muscle response. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | 06351 | South Korea |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Baseline and about 10 days (immediately after brain stimulation sessions) |
| 9-hole pegboard test | The test is a standardized, quantitative assessment used to measure finger dexterity of a patient. | Baseline and about 10 days (immediately after brain stimulation sessions) |
| Grip & Tip pinch strength test | The test is to measure the maximum isometric strength of hand, forearm, and finger muscles. | Baseline and about 10 days (immediately after brain stimulation sessions) |
| Box & Block test | The test is used to measure the gross manual dexterity of a patient, or of a person using an upper limb prosthetic device. | Baseline and about 10 days (immediately after brain stimulation sessions) |
| Fugl-Meyer Assessment | The score is a stroke-specific, performance-based impairment index. The degree of impairment of upper and lower limbs is measured. | Baseline and about 10 days (immediately after brain stimulation sessions) |
| Finger tapping test | Response time is measured during finger tapping task. | Baseline and about 10 days (immediately after brain stimulation sessions) |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |