Impact of Yogurt on Gastrointestinal Health, Regularity, and Thoughts

Impact of Yogurt on Gastrointestinal Health, Regularity, and Thoughts

This study aims to test the central hypothesis that adding to the diet daily yogurt provides beneficial effects on digestive health and subjective mood in healthy adults.

This clinical trial will include a 4-week lead-in period and a 2-week treatment period. The lead-in period will be devoid of all supplemental and dietary probiotics, fermented dairy products, and fermented foods. Participants will be asked to refrain from consuming all supplemental and dietary probiotics, fermented dairy products, and fermented foods throughout the entire study. During the treatment period, participants will be given yogurt with sugar. This trial will serve as a continuation of the NECTAR Study (NCT04187950).

Inclusion Criteria:

• Males and females
• Between the ages of 22-64 years at the time of consent
• Body mass index of 18.5 to 29.9 kg/m^2.
• Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to complete the cognitive task (below 20/20 vision).
• Ability to drop off fecal sample within 30 minutes of defecation
• Have between 3-6 bowel movements per week
• Have completed the NECTAR Study (NCT04187950)

Exclusion Criteria:

• Current pregnancy, lactation, or post-menopausal
• Tobacco use
• Honey allergy or intolerance
• Dairy allergy, lactose intolerance
• Food dye allergy/intolerance
• Prior physician diagnosed gastrointestinal disease (chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers, hepatitis, or gastroesophageal reflux disease (GERD))
• Current use or use of antibiotics in the past 3 months
• Current use of any of the following types of medications: laxatives, anti-diarrhea medications, narcotics, enemas, antispasmodics, anticonvulsants, prescription proton pump inhibitors, prokinetic agents, histamine-2 Rc antagonists (prescription GERD medication)
• Body mass index > 29.9 kg/m^2
• Prior malabsorptive bariatric surgery (i.e. gastric bypass, sleeve gastrectomy)
• Restrictive bariatric surgery (i.e. adjustable gastric band) within the past 5 years
• Concurrent enrollment in another dietary, exercise, or medication study (except for the NECTAR Study (NCT04187950))