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The purpose of this study is to determine whether a structured 12-week program designed for older adults will improve physical function and, in parallel, circulating biomarkers of aging
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| Measure | Description | Time Frame |
|---|---|---|
| Change in repeated chair rise time | Chair stand test where participants will perform a chair rise movement for five repetitions. The series of 5 repetitions will be timed and measured in seconds. | Baseline to end of study, approximately 14 weeks |
| Change in plasma protein levels reflective of biological age | Blood samples will be obtained at baseline and at 12 weeks. The concentration of target proteins (pg/mL) in the plasma will be measured and compared between baseline and week 12. | Baseline, week 12 |
| Change in expression of senescence-related genes in blood cells | Blood samples will be obtained at baseline and at 12 weeks. The expression of senescence-related genes (arbitrary units) will be measured in immune cells isolated from whole blood and compared between baseline and week 12. | Baseline, week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Self-reported Physical Function | Measured using the Physical Component Scale (PCS) from the 12-Item short form general health survey (SF-12). | Baseline, week 12 |
| Change in Performance-based Physical Function |
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Inclusion Criteria:
Exclusion Criteria:
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The target population consists of The Dan Abraham Healthy Living Center (DAHLC) members 60 years of age and older who plan to participate in the Active Older Adult Program.
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| Name | Affiliation | Role |
|---|---|---|
| Nathan LeBrasseur, PhD, MS | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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Blood-derived plasma and CD3+ T-cells
Measured using the timed up-and-go test (seconds to complete).
| Baseline, week 12 |
| Change in Mental Function | Measured using the Mental Component Scale (MCS) from the 12-Item short form general health survey (SF-12) | Baseline, week 12 |
| Change in self-assessment of well-being | Measured using a linear analogue self-assessment scale of well-being from 0 ("as bad as it can be") to 10 ("as good as it can be") of mental, physical, emotional, and spiritual well-being, level of social activity, and overall quality of life during the past week | Baseline, week 12 |