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To determine whether the neuropeptide oxytocin (OXT) and vassopressin (AVP) influence moral decision making
In a double-blind, between- subject placebo (PLC) controlled design, subjects will first complete a series of questionnaires in terms of mood, clinical symptoms, and traits. After that their moral judgment and emotion towards both verbal descriptions of moral dilemma scenarios and pictures of specific interpersonal ones will be assessed and the effect of intranasal OXT and AVP between both male and female healthy subjects will be investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oxytocin group | Experimental | subjects with oxytocin treatment |
|
| vasopressin group | Experimental | subjects with vasopressin treatment |
|
| placebo group | Placebo Comparator | subjects with placebo treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | intranasal administration of oxytocin (24 IU) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of OXT and AVP on behavioral index of moral decision task | intensity of feelings | 45 mins - 105 mins |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Keith M. Kendrick | University of Electronic Science and Technology of China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xiaoxiao Zheng | Sichuan | Sichuan | 611731 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38769372 | Derived | Zheng X, Wang J, Yang X, Xu L, Becker B, Sahakian BJ, Robbins TW, Kendrick KM. Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame. Mol Psychiatry. 2024 Nov;29(11):3475-3482. doi: 10.1038/s41380-024-02590-w. Epub 2024 May 20. |
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| ID | Term |
|---|---|
| D003919 | Diabetes Insipidus |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| D014667 | Vasopressins |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Vasopressin |
| Drug |
intranasal administration of vasopressin (20 IU) |
|
| Placebo | Drug | intranasal administration of placebo |
|
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D010900 | Pituitary Diseases |
| D004700 | Endocrine System Diseases |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009479 | Neuropeptides |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |